CAS: 3952-78-1; 2,2'-(((3,4-Dihydroxy-9,10-Dioxo-9,10-Dihydroanthracen-2-yl)Methyl)Azanediyl)Diacetic Acid

该化合物是已知的具有利用金属离子形成稳定复合体能力的铬化剂,来自天然染色的Alizarin,具有有选择地与各种过渡金属结合的能力,使其在分析化学和环境应用中有用.该复合体通常具有亮色,可视其复杂的金属离子而有所不同,并经常用于色度测量.Alizarin 复合体在水和有机溶剂中溶解,在不同化学环境中强化其多功能性.其铬化特性使其在金属离子提取,水处理和各种化学分析中的再试剂等应用中具有价值.此外,它在生物系统中具有潜在用途,可以影响金属离子的可得性和生物活性.

结构式图片

相似化合物

72-48-0 455303-00-1 3952-78-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号50-00-0 甲醛 | CAS号72-48-0 1,2-二羟基蒽醌,茜素 | CAS号142-73-4 亚氨基二乙酸

合成工艺路线路线简述

  • 合成目标产物 Alizarin Complexone 主要起始原料 Formaldehyde And Alizarin And Iminodiacetic Acid
  • (文献来源)合成步骤主要原料 Formaldehyde 和 Alizarin 和 Iminodiacetic Acid
聚合甲醛,1,2-二羟基蒽醌,亚氨基二乙酸置于sodium Hydroxide体系中,化学反应生成 茜素络合指示剂
参考文献:Belcher Et Al.,Journal Of The Chemical Society,1958,P. 2390,2392
标题:Belcher Et Al.,Journal Of The Chemical Society,1958,P. 2390,2392

海关参考信息

专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

专利号:US-7888116-B2
优先权日:2004-07-22
标 题 :Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases
发明人:EGAN JOSEPHINE M; DOYLE MAIRE E
权利人:US HEALTH
摘要:Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.

专利号:US-2005202459-A1
优先权日:2003-09-23
标 题 :Intercalation-mediated synthesis of polymers

专利号:WO-9729091-A1
优先权日:1996-02-09
标题:Balanol analogues
发明人:NIELSEN JOHN; LYNGSOE LARS OLE
权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE
摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.

专利号:US-7368560-B2
优先权日:2003-09-23
标题:Intercalation-mediated synthesis of polymers
发明人:HUD NICHOLAS V
权利人:GEORGIA TECH RES INST
摘要:Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or non-natural biopolymer subunits using natural biopolymer templates. Other aspects provide compositions and methods for synthesizing biopolymers using a template with a non-natural backbone on non-natural biopolymer subunits.
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主要参考文献


1: Zou Z, He D, Cai L, He X, Wang K, Yang X, Li L, Li S, Su X. Alizarin Complexone Functionalized Mesoporous Silica Nanoparticles: A Smart System Integrating Glucose-Responsive Double-Drugs Release and Real-Time Monitoring Capabilities. ACS Appl Mater Interfaces. 2016 Apr 6;8(13):8358-66. doi: 10.1021/acsami.5b12576. Epub 2016 Mar 25. Chinese. doi: 10.1016/j.ecoenv.2012.01.009. Epub 2012 Jan 31. doi: 10.1111/j.1095-8649.2009.02383.x. doi: 10.1016/j.jhazmat.2010.06.028. Epub 2010 Jun 12. Japanese.

合成参考文献


参考文献:10.1007/s00774-011-0291-7
摘要:Burt-Pichat B, Follet H, Toulemonde G, Arlot M, Delmas P, Chapurlat R. Methodological approach for the detection of both microdamage and fluorochrome labels in ewe bone and human trabecular bone. Journal of Bone and Mineral Metabolism. 2011 Jul 13;29(6):756–64. doi: 10.1007/s00774-011-0291-7.
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