聚合甲醛,1,2-二羟基蒽醌,亚氨基二乙酸置于sodium Hydroxide体系中,化学反应生成 茜素络合指示剂 参考文献:Belcher Et Al.,Journal Of The Chemical Society,1958,P. 2390,2392 标题:Belcher Et Al.,Journal Of The Chemical Society,1958,P. 2390,2392
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2018312534-A1 优先权日:2015-10-16 标题:Fluorescent anticancer platinum drugs 发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA 权利人:INVICTUS ONCOLOGY PVT LTD 摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.
专利号:US-7888116-B2 优先权日:2004-07-22 标 题 :Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases 发明人:EGAN JOSEPHINE M; DOYLE MAIRE E 权利人:US HEALTH 摘要:Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.
专利号:US-2005202459-A1 优先权日:2003-09-23 标 题 :Intercalation-mediated synthesis of polymers
专利号:WO-9729091-A1 优先权日:1996-02-09 标题:Balanol analogues 发明人:NIELSEN JOHN; LYNGSOE LARS OLE 权利人:AUDA PHARMACEUTICALS APS; NIELSEN JOHN; LYNGSOE LARS OLE 摘要:The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid-phase synthesis of the analog variants of balanol whereby a high molecular diversity is introduced. The synthetic scheme is based on a retrosynthetic analysis of the native structure which revealed three main building blocks suitable as templates for modification. The dicarboxy-functional moiety can be immobilised to the polymer support either as the monoallyl ester or as the internal anhydride. The libraries produced by the method are especially suited for high throughput screening of potential drug candidates for the treatment of mammals, especially humans.
专利号:US-7368560-B2 优先权日:2003-09-23 标题:Intercalation-mediated synthesis of polymers 发明人:HUD NICHOLAS V 权利人:GEORGIA TECH RES INST 摘要:Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or non-natural biopolymer subunits using natural biopolymer templates. Other aspects provide compositions and methods for synthesizing biopolymers using a template with a non-natural backbone on non-natural biopolymer subunits.
1: Zou Z, He D, Cai L, He X, Wang K, Yang X, Li L, Li S, Su X. Alizarin Complexone Functionalized Mesoporous Silica Nanoparticles: A Smart System Integrating Glucose-Responsive Double-Drugs Release and Real-Time Monitoring Capabilities. ACS Appl Mater Interfaces. 2016 Apr 6;8(13):8358-66. doi: 10.1021/acsami.5b12576. Epub 2016 Mar 25. Chinese. doi: 10.1016/j.ecoenv.2012.01.009. Epub 2012 Jan 31. doi: 10.1111/j.1095-8649.2009.02383.x. doi: 10.1016/j.jhazmat.2010.06.028. Epub 2010 Jun 12. Japanese.
合成参考文献
参考文献:10.1007/s00774-011-0291-7 摘要:Burt-Pichat B, Follet H, Toulemonde G, Arlot M, Delmas P, Chapurlat R. Methodological approach for the detection of both microdamage and fluorochrome labels in ewe bone and human trabecular bone. Journal of Bone and Mineral Metabolism. 2011 Jul 13;29(6):756–64. doi: 10.1007/s00774-011-0291-7.