CAS: 379270-35-6; Phenyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-yl)Propan-2-yl)Oxy)Methyl)Phosphonate

上下游产品

CAS号379270-37-8 替诺福韦艾拉酚胺 | CAS号383365-04-6 磷丙替诺福韦

泰诺福韦置于氯化亚砜,Potassium Hydroxide体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 20.0H,反应生成替诺福韦艾拉酚胺中间体1
参考文献:一种富马酸替诺福韦艾拉酚胺关键中间体的 制备方法
标题:一种富马酸替诺福韦艾拉酚胺关键中间体的 制备方法
摘要:本发明本发明属于药物合成领域,涉及一种药物中间体的制备方法,特别涉及富马酸替诺福韦艾拉酚胺关键中间体的制备方法.本发明提供一种新的制备高非对映异构体纯度的富马酸替诺福韦艾拉酚胺关键中间体2的方法,该方法具有反应时间短,副产物少,操作简单,产品质量好,反应收率高,更适于工业化生产等特点.

专利信息

专利号:US-11186599-B2
优先权日:2018-06-12
标题 :Phosphonamide ester compound, salt thereof, related crystal form thereof, preparation method therefor and use thereof
发明人：TIAN QIANG; WANG TIANMING; LIU WEI; ZHANG BAOLEI; ZHAO MINGLIANG; LIANG YUFENG; CAI JIAQIANG; WANG LICHUN; WANG JINGYI
权利人:SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD
摘要:The present invention relates to compounds represented by formula (I) and formula (II) and a chiral synthesis and chiral isolation method therefor, further relating to a salt and crystal form of the compound represented by formula (I), a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the preparation of a medicament used for the treatment of a viral infectious disease such as hepatitis B.