丙烯醛置于盐酸体系中,化学反应生成3-氯丙醛二乙醇缩醛 参考文献:Hersant; Linnell,Quarterly Journal Of Pharmacy And Pharmacology,1931,Vol. 4,P. 62,86 标题:Hersant; Linnell,Quarterly Journal Of Pharmacy And Pharmacology,1931,Vol. 4,P. 62,86
专利号:US-5576426-A 优先权日:1988-08-30 标 题:Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose 发明人:WONG CHI-HUEY; DURRWACHTER JOHN R; PEDERSON RICHARD L 权利人:SEARLE & CO 摘要:The present invention relates to aldolase catalyzed stereo-selective synthesis of sugars and compositions of matter comprising arabinohexulose, xyloheptulose, threohexulose, and xylohexulose.
专利号:WO-2014087110-A1 优先权日:2012-12-07 标 题:Method for synthesising an addition salt with a pharmaceutically acceptable acid of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, and the associated crystalline forms 发明人:PIERRY CAMILLE; ROBERT NICOLAS; LECOUVE JEAN-PIERRE; LETELLIER PHILIPPE 权利人:SERVIER LAB 摘要:A method for the industrial synthesis of an addition salt with a pharmaceutically acceptable acid of 4-{3-[ cis -hexahydrocyclopenta[ c ]pyrrol-2(1 H )-yl]propoxy}benzamide of formula (I), in which ΗΧ represents a pharmaceutically acceptable acid, and the associated crystalline forms. Drugs
专利号:US-8952179-B2 优先权日:2011-06-08 标 题:Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it 发明人:ROBERT NICOLAS; LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; GAILLARD MARINA; MEUNIER LOIC; LETELLIER PHILIPPE; BOIRET MATHIEU 权利人:SERVIER LAB; SERVIER LAB 摘要:Industrial synthesis process for the compound of formula (I):
专利号:WO-2005111026-A1 优先权日:2004-04-13 标题 :Novel method of synthesising 1,3-dihydro-2h-3-benzazepin-2-one derivatives and use thereof in the synthesis of ivabradine and the salts thereof for addition to a pharmaceutically acceptable acid
专利号:US-2565537-A 优先权日:1949-08-08 标题:Synthesis of beta-cyanopropionaldehyde and related compounds 发明人:WARNER DONALD T; MOE OWEN A 权利人:GEN MILLS INC
[参考文献]: J L Kelley, Et Al. Synthesis And Biological Activity Of An Acyclic Analogue Of 5,6,7,8-Tetrahydrofolic Acid, N-[4-[[3-(2,4-Diamino-1,6-Dihydro-6-Oxo-5- Pyrimidinyl)Propyl]Amino]-Benzoyl]-L-Glutamic Acid. J Med Chem. 1990 Feb;33(2):561-7.
合成参考文献
摘要:Zhang, Z.; Tong, R., Science of Synthesis Knowledge Updates, (2019) 2, 397. 摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 875.