CAS: 351-36-0; N-(3-(Trifluoromethyl)Phenyl)Acetamide

该化合物是一种有机化合物,其特点是其乙酰功能组附于一个三氟甲基替代成分的苯环上,该化合物一般是一种固体或晶体物质,由于三氟甲基组的存在,其独特的化学特性为已知,这增加了其亲脂性,并可能影响其再活性和生物活动.三氟甲基组已知具有独特的电子特性,使该化合物有可能用于各种用途,包括药物和农用化学品.

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CAS号98-16-8 间三氟甲苯胺 | CAS号108-24-7 乙酸酐 | CAS号887144-97-0 3,3-二甲基-1-(三氟甲基... | CAS号78887-39-5 3-乙酰胺基苯硼酸 | CAS号106-95-6 烯丙基溴 | CAS号103-84-4 N-乙酰苯胺 | CAS号507-09-5 硫代乙酸 | CAS号348-90-3 N-[4-氯-3-(三氟甲基)... | CAS号75-36-5 乙酰氯 | CAS号393-12-4 4'-硝基-3'-(三氟甲基)乙酰苯胺 | CAS号344-62-7 2'-(三氟甲基)乙酰苯胺 | CAS号393-12-4 4'-硝基-3'-(三氟甲基)乙酰苯胺 | CAS号395-99-3 N-[2-nitro-5-(t... | CAS号387-19-9 N-[2-nitro-3-(t... | CAS号454-92-2 3-三氟甲基苯甲酸 | CAS号364-13-6 2-(三氟甲基)-1,4-亚苯基二胺 | CAS号402-14-2 3-氨基-4-硝基三氟甲苯 | CAS号393-11-3 4-硝基-3-三氟甲基苯胺 | CAS号386-71-0 2-硝基-3-(三氟甲基)苯胺 | CAS号41513-05-7 4′-溴-3′-(三氟甲基)乙酰苯胺

合成工艺路线路线简述

    📜间三氟甲基苯乙酮置于甲烷磺酸,叠氮化四丁基铵体系中,用 乙二醇二甲醚 用作溶剂,化学反应 0.08H,以77%的收率获得3-乙酰氨基三氟甲苯
    参考文献:连续流微反应器中dme溶液中酮的schmidt反应
    标题:连续流微反应器中dme溶液中酮的schmidt反应
    摘要:施密特反应是在强酸存在下用氢偶氮酸处理,可将酮直接转化为酰胺,已广泛应用于有机合成中.在这种交流中,酮的schmidt反应在连续流动的微反应器中的dme溶液中进行,得到酰胺产物.微反应器的封闭式小体积功能使该反应安全,快速且具有成本效益.
    Doi:10.1021/op500269J

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    专利信息


    专利号:US-8513241-B2
    优先权日:2008-03-28
    标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
    权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
    摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    专利号:CN-116813524-A
    优先权日:2023-06-30
    标 题:A kind of synthesis method of 2-substituted-3-trifluoromethylselenoindole compound

    专利号:EP-0470000-B1
    优先权日:1990-08-02
    标 题:Allylation reagent and method of synthesis using it

    专利号:CN-115232019-B
    优先权日:2022-08-05
    标题:A kind of synthesis method of 3-acetamidotrifluorotoluene compounds

    专利号:CN-110668955-A
    优先权日:2018-07-02
    标题 :Synthesis method of o-amino benzotrifluoride

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    合成参考文献


    摘要:Toxicology and Applied Pharmacology., 19(20), 1971 []
    摘要:Satoh, T.; Miura, M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 204.
    摘要:Dornan, P. K.; Dong, V. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 156.
    摘要:Ros, A.; Fernández, R.; Lassaletta, J. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 431.
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