4-叠氮基-1-丁胺 在 Palladium On Activated Charcoal 盐酸,氢气体系中,用 甲醇作为反应溶剂,反应 18.0H,以90%的收率获得putrescine DihydroChloride 参考文献:Curtius Rearrangement Of ω-Azido Acid Chlorides: Access To The Corresponding ω-Azido Substituted Amines And Carbamates,Useful Building Bloks For Polyamine Syntheses 标题:Curtius Rearrangement Of ω-Azido Acid Chlorides: Access To The Corresponding ω-Azido Substituted Amines And Carbamates,Useful Building Bloks For Polyamine Syntheses 摘要:用三甲基硅叠氮化物处理 ï-Azido 酸氯化物,可得到 ï-Azido 异氰酸酯,这些异氰酸酯很容易以良好的产率转化成相应的 ï-Azidoamines 或 ï-Azidocarbamates.然后,通过催化氢化或有机二氯硼烷还原烷基化,可制备 1,3-和 1,4-二胺二氢氯化物. Doi:10.1055/S-1996-4438
专利信息
专利号:US-6150163-A 优先权日:1996-07-25 标 题 :Chondrocyte media formulations and culture procedures 发明人:MCPHERSON JOHN M; YAEGER PETER C; BROWN MARIE E; HANLON JAMES G; BINETTE FRANCOIS 权利人:GENZYME CORP 摘要:One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In particular, the defined medium is useful in culturing fibroblasts, especially chondrocytes. Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes and enhancing the synthesis of a cartilage specific matrix using tumor growth factor beta (TGF-β). Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes using the combination of TGF-βand IGF.
专利号:US-2023095750-A1 优先权日:2019-12-12 标 题:Flow chemistry synthesis of isocyanates 发明人:BURKART MICHAEL D; PHUNG HAI THIEN AN 权利人:UNIV CALIFORNIA 摘要:The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.
专利号:US-2005027005-A1 优先权日:2003-08-02 标题 :Nutrient compositions and methods for sustenance and promotion of positive metabolic energy levels in a targeted manner 发明人:BOLDT MATTHIAS 摘要:Nutrient compositions and methods that sustain and promote positive metabolic energy levels in a targeted manner are disclosed. Methods utilize endogenous energy stores (fat oxidation), increase use of those stores (increasing transport rate), increase available energy (increasing the ability to perform ADP to ATP phosphorylation,) as well as decrease catabolism and increase protein synthesis. Compositions are also disclosed, and include Mono- or Dicreatine-HMB salt; Putrescine Dihydrochloride; Alanine; L-Glutamine, which may be combined with Alanine in a 1:2 to 2:1 molecular ratio; Trimethylglycine; and Guanidinopropionic Acid.
专利号:EP-4073032-A1 优先权日:2019-12-12 标 题:Flow chemistry synthesis of isocyanates
专利号:WO-2021119606-A1 优先权日:2019-12-12 标 题 :Flow chemistry synthesis of isocyanates
专利号:WO-0034226-A1 优先权日:1998-12-10 标 题 :Polyamine transport inhibitors 发明人:POULIN RICHARD; AUDETTE MARIE; CHAREST-GAUDREALT RENE 权利人:UNIV LAVAL; ILEX ONCOLOGY INC; POULIN RICHARD; AUDETTE MARIE; CHAREST GAUDREALT RENE 摘要:The application discloses synthetic derivatives of original polyamines in which a carbon atom to the original polyamine comprises an amide group inhibits the e cellular uptake of a natural polyamine by specifically binding a cellular transporter for a natural polyamine . The synthetic derivatives are used to inhibit the activity of a natural polyamine transporter, in the treatment of disorders involving unrestrained cell proliferation and/or differentiation where control of polyamine transport is required When used in combination with a n inhibitor of polyamine synthesis.