CAS: 3304-51-6; H-Orn(Z)-Oh

该化合物是一种受保护的氨基酸衍生物,广泛用于peptide合成和制药研究,该化合物在-氨基边链的赖氨基(Cbz)中具有保护性组,确保固相或溶相-peptide联结期间有选择性的再活动.它的气压(2S)配置在合成应用中保持立体化学完整性.Cbz组在酸性和中性条件下提供稳定性,同时通过氢解随时切开,使其适合正向保护战略.这种衍生物在建造复合的丙基苯基时特别有用,因为受控制的脱保是关键.高纯度和连续性能使得研究人员在氨酸修改中需要精确的侧链保护时,成为可靠的选择.

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CAS号3184-13-2 L-鸟氨酸盐酸盐 | CAS号501-53-1 氯甲酸苄酯 | CAS号70-26-8 鸟氨酸 | CAS号5874-56-6 For-DL-Orn(Z)-OH | CAS号74-79-3 L-精氨酸 | CAS号2480-93-5 N-叔丁氧羰基-N'-苄氧羰基... | CAS号70-26-8 鸟氨酸 | CAS号138775-07-2 (S)-2-((((9H-芴-... | CAS号1159-15-5 N-对甲苯磺酰基-L-精氨酸 | CAS号133565-49-8 B°C-L-硫代瓜氨酸叔丁酯 | CAS号16748-29-1 N2-甲基-L-鸟氨酸 | CAS号53054-07-2 noha | CAS号5874-75-9 N5-苄氧羰基-L-鸟氨酸甲酯盐酸盐

合成工艺路线路线简述

    📜L-鸟氨酸盐酸盐置于lithium Hydroxide,Sodium Hydroxide体系中,化学反应生成 N'-Cbz-L-鸟氨酸
    参考文献:Multigram Synthesis Of Ng-Methyl-(L)-Arginine And Its Analytical Characterization
    标题:Multigram Synthesis Of Ng-Methyl-(L)-Arginine And Its Analytical Characterization
    摘要:A Multigram Preparation And Analytical Characterization Of N(G)-Methyl-(L)-Arginine (L-Nmma) 1,The Most Important Inhibitor Of The Biosynthesis Of Endothelium-Derived Relaxing Factor (Edrf),Is Reported.
    DOI:10.1080/00397919108020795

    海关参考信息

    专利信息


    专利号:US-9416113-B2
    优先权日:2011-02-10
    标 题:Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine
    发明人：FREEMAN JOHN J; STAMPER ADRIENNE; HEITMANN MELISSA
    权利人:MANNKIND CORP; MANNKIND CORP
    摘要:The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the cyclocondensation and purification of N-protected 3,6-(aminoalkyl)-2,5-diketopiperazines from N-protected amino acids. Disclosed embodiments describe methods for the synthesis of 3,6-bis-[N-protected aminoalkyl]-2,5-diketopiperazine comprising heating a mixture of an amino acid in the presence of a catalyst in an organic solvent. The catalyst is selected from the group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid and phosphorous pentoxide among others. The solvent is selected from the group comprising: dimethylacetamide, N-methyl-2-pyrrolidone, diglyme, ethyl glyme, proglyme, ethyldiglyme, m-cresol, p-cresol, o-cresol, xylenes, ethylene glycol and phenol among others.

    专利号:US-9796688-B2
    优先权日:2004-08-20
    标 题:Catalysis of diketopiperazine synthesis
    发明人：STEVENSON JOHN J; MOYE-SHERMAN DESTARDI
    权利人:MANNKIND CORP
    摘要:Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ε-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.

    专利号:US-2019031621-A1
    优先权日:2004-08-20
    标 题:Catalysis of diketopiperazine synthesis

    专利号:US-2010087642-A1
    优先权日:2004-08-20
    标 题:Catalysis of Diketopiperazine Synthesis

    专利号:US-2020190041-A1
    优先权日:2004-08-20
    标题:Catalysis of Diketopiperazine Synthesis

    专利号:US-2012178935-A1
    优先权日:2004-08-20
    标题:Catalysis of Diketopiperazine Synthesis

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    合成参考文献


    摘要:Compound: L-Ornithine, N5-[(phenylmethoxy)carbonyl]-, homopolymer
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