CAS: 30044-51-0; S-Tert-Butylmercapto-L-Cysteine

相似化合物

30044-61-2 73724-43-3 501326-55-2

上下游产品

2-methylpropan-2-thiol3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine Nps-γ-Glu(α-OtBu)-Cys(StBu)-OH N-2-Phenyl-iso-propyloxycarbonyl-S-tert.-butylthio-cystein-dicyclohexylammoniumsalz (R)-2-Benzyloxycarbonylamino-3-tert-butyldisulfanyl-propionic acid

📜叔丁基硫醇,S-(Methoxycarbonylsulfenyl)Cysteine Hydrochloride置于三乙胺体系中,用 甲醇 作为反应溶剂,以90%的收率获得产物s-叔丁基硫-L-半胱氨酸
参考文献:一种制备 S-(烷基亚硫基)半胱氨酸的简便方法
标题:一种制备 S-(烷基亚硫基)半胱氨酸的简便方法
摘要:摘要 描述了一种简便制备 S-(烷基亚硫基)半胱氨酸的通用方法.它采用 S-(甲氧基羰基硫基) 半胱氨酸盐酸盐 [h-Cys(Scm)-Oh.Hcl] 作为易于获得的母体硫醇活化半胱氨酸衍生物.
DOI:10.1080/00397919408011734

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:EP-4041249-A1
优先权日:2019-10-10
标题 :Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:CN-115286671-A
优先权日:2022-07-13
标题 :A kind of oligomeric nucleic acid-thiazolidine compound, synthesis method and application

专利号:CN-115286671-B
优先权日:2022-07-13
标 题 :A kind of oligomeric nucleic acid-thiazolidine compound, synthesis method, application