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溴代十四烷置于potassium Carbonate,Lithium Hydroxide体系中,用 乙醇,二甲基亚砜,丙酮 用作溶剂,化学反应 96.0H,反应生成十四烷基硫代乙酸
参考文献:硫发挥作用:新型硫醚官能化的咪唑鎓离子液晶的合成和介晶性质
标题:硫发挥作用:新型硫醚官能化的咪唑鎓离子液晶的合成和介晶性质
摘要:从2-巯基乙酸甲酯合成了新型硫醚连接的咪唑鎓离子液晶.通过差示扫描量热法(dsc),偏振光学显微镜(pom)和x射线衍射确定了介晶性质.所有的介晶均表现出具有强相互指状的双层结构的近晶a中间相几何形状.硫醚连接的咪唑鎓盐与相应的胺和酰胺连接的咪唑鎓盐以及简单的n-烷基咪唑鎓盐的比较表明,中间相宽度和稳定性均随着连接单元柔软度的增加而增加,从而表明了有益的作用.硫.另外,连接单元长度的增加减少了烷基链的叉指.
Doi:10.1016/j.Tet.2014.03.050

专利信息

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.