CAS: 261762-39-4; 2-Chloro-3,6-Difluorobenzaldehyde

上下游产品

1-chloro-2,5-difluorobenzene N,N-dimethyl-formamide 2-chloro-3,6-difluoro-benzaldehyde oxime 1-(2-chloro-3,6-difluorophenyl)ethan-1-ol 1-(1H-benzo[d]imidazol-6-yl)-5-(2-chloro-3,6-difluorophenyl)-3-hydroxy-4-methyl-1H-pyrrol-2(5H)-one

2,5-二氟氯苯,N,N-二甲基甲酰胺置于lithium Diisopropyl Amide体系中,用 四氢呋喃 用作溶剂,化学反应 0.75H,以71%的收率获得2-氯-3,6-二氟苯甲醛
参考文献:(Aza)Pyridopyrazolopyrimidinones And Indazolopyrimidinones And Their Use
标题:(Aza)Pyridopyrazolopyrimidinones And Indazolopyrimidinones And Their Use
摘要:本申请涉及新型取代的(氮杂)吡啶吡唑吡嘧啶酮和吲唑吡嘧啶酮,以及它们的制备方法,这些化合物可单独或组合使用于治疗和/或预防疾病的方法中,特别是用于治疗和/或预防患有或不患有基础遗传或获得性出血性疾病的患者的急性和复发性出血,其中出血与来自月经过多,产后出血,出血性休克,创伤,手术,移植,中风,肝病,遗传性血管性水肿,鼻血和血液性关节积血后的滑膜炎和软骨损伤等疾病或医疗干预有关.

专利信息

专利号:US-2014088114-A1
优先权日:2011-05-16
标 题:Fused bicyclic kinase inhibitors
发明人：JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING
权利人:JIN MEIZHONG; MULVIHILL MARK J; STEINIG ARNO G; WANG JING; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula (I), pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by at least one of MET, RON, ALK, IR, or IGF-1R. This Abstract is not limiting of the invention.