CAS: 2130-96-3; Boc-Tyr(Bzl)-Oh

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📜Boc-L-酪氨酸甲酯置于四丁基碘化铵,Potassium Carbonate,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,丙酮 用作溶剂,化学反应生成Boc-O-苄基-L-酪氨酸
参考文献:(-)-螺鞘亮碱的全合成
标题:(-)-螺鞘亮碱的全合成
摘要:简而言之:高效的仿生方法可以完全合成(-)-螺环十二烷(1),这是一种富含杂原子的抗菌海洋天然产物.由高价碘试剂介导的两个关键的氧化反应之一被用来构建螺环中心,另一个可以在倒数第二个步骤中安装甲胺侧链.
Doi:10.1002/anie.201708110

专利信息

专利号:US-9988492-B2
优先权日:2013-09-30
标题:Methods for post-fabrication functionalization of poly(ester ureas)
发明人：BECKER MATTHEW; LIN FEI
权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON
摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4212795-A
优先权日:1978-11-13
标题:Cyclization of peptides
发明人：HUGHES JOHN L; LIU ROBERT C; SEYLER JAY K
权利人:ARMOUR PHARMA
摘要:The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.

专利号:US-3953416-A
优先权日:1971-12-20
标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
发明人：FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

专利号:US-4301045-A
优先权日:1977-05-02
标 题:Synthesis of peptides
发明人：KAISER EMIL; COLESCOTT ROBERT L
权利人:ARMOUR PHARMA
摘要:Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing Pro-Asp-CH2- or Pro-Asn-CH2- at one end of an amino acid chain, being the resin and Pro, Asp and Asn being the residues of the amino acids proline, aspartic acid and asparagine; and processes for the preparation of such resin peptides.

专利号:US-4060689-A
优先权日:1976-02-20
标题:Vinylbenzyl esters of n-boc-amino acids
发明人：HARRIS NICHOLAS D
权利人:MORTON NORWICH PRODUCTS INC
摘要:There is described herein the preparation of vinylbenzyl esters of N-BOC amino acids which upon polymerization with styrene and divinylbenzene provide insoluble polymers useful as starting materials for the solid phase synthesis of peptides.