CAS: 1631-70-5; Benzyldimethylsilane

相似化合物

770-09-2 1833-31-4 17095-20-4

上下游产品

CAS号1833-31-4 苄基二甲基氯硅烷 | CAS号10025-78-2 三氯氢硅 | CAS号676-58-4 甲基氯化镁 | CAS号6921-34-2 苄基氯化镁 | CAS号100-44-7 氯化苄 | CAS号75-78-5 二甲基二氯硅烷 | CAS号56633-16-0 benzyl-hydroxy-... | CAS号1833-27-8 1,3-二苄基四甲基二硅烷 | CAS号61676-43-5 3-[benzyl(dimet... | CAS号61676-44-6 acetic acid,3-[...

📜苄基二甲基氯硅烷置于sodium Tetrahydroborate体系中,用 乙腈 用作溶剂,以78%的收率获得苄基二甲基硅烷
参考文献:三烷基-和二烷基芳基甲硅烷基硼烷的一般合成:有机合成中的多功能硅亲核试剂
标题:三烷基-和二烷基芳基甲硅烷基硼烷的一般合成:有机合成中的多功能硅亲核试剂
摘要:与碳基亲核试剂相比,目前可用的硅基亲核试剂的数量仍然有限,这极大地阻碍了可合成的硅基分子的结构多样性.鉴于碳基硼亲核试剂的高合成效用和易于处理,硅基硼亲核试剂,即甲硅烷基硼烷,近年来作为由过渡金属催化剂或碱活化的亲核甲硅烷基化试剂引起了相当大的兴趣.然而,实际可获得的甲硅烷基硼烷的范围仍然有限.特别是,空间位阻和功能化甲硅烷基硼烷的制备仍然是一个重大挑战.在这里,我们报告了使用铑和铂催化剂将氢硅烷与双(频哪醇)二硼直接硼化的情况,这允许合成带有庞大烷基和官能团的新三烷基甲硅烷基硼烷,以及难以通过使用碱金属的常规方法合成的新二烷基芳基甲硅烷基硼烷.我们进一步证明,这些化合物可用作有机转化中的硅亲核试剂,与先前报道的方法相比,这显着扩大了可合成的有机硅化合物的范围.因此,本研究有望激发开发具有理想特性的新型含硅生物活性分子和有机材料的有效方法.我们还报告了 I-Pr3Si-B(pin)与 Meli
Doi:10.1021/jacs.0C03011

专利信息

专利号:US-5145957-A
优先权日:1988-03-18
标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-5087703-A
优先权日:1988-01-28
标题 :Process for synthesis of FK-506 intermediates
发明人：VOLANTE RALPH P; ASKIN DAVID; SHINKAI ICHIRO; RYAN KENNETH M
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C10-C18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.

专利号:US-4914220-A
优先权日:1988-05-23
标题 :Process for synthesis of E-2-methyl-α,β-unsaturated aldehydes
发明人：DESMOND RICHARD; MILLS SANDER G; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of E-2-methyl-α,β-unsaturated aldehydes, which are useful as intermediates in the synthesis of the macrolide structure of the immunosuppressant FK-506. These compounds are also useful as ultraviolet radiation absorbers.

专利号:EP-0269236-B1
优先权日:1986-10-24
标题:Process for synthesis of a chiral azetidinone
摘要:A process is described for the stereo-controlled synthesis of 3-(R)-3-[1'-(R)-hydroxyethyl]-4-(R)-benzoyl-2-oxo-1-aze tidines and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:EP-0333268-A1
优先权日:1988-03-18
标题:Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereo-­controlled synthesis of (3R,4R)-3-[(1R)-1-hydroxy­ethyl]-4-benzoyloxyazetidin-2-ones and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-8013157-B2
优先权日:2006-12-20
标题:Synthesis of unsaturated piperidines from piperidones with a silyl reagent
发明人：MANI NEELAKANDHA S; MORRILL CHRISTIE
权利人:JANSSEN PHARMACEUTICA NV
摘要:Syntheses of unsaturated piperidines from piperidones through a silyl piperidine reagent via the Shapiro reaction and palladium-catalyzed cross-coupling reactions with organo halides.