CAS: 162059-94-1; (4As,6Ar,6Ar,6Br,8Ar,12Ar,14Bs)-10-[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxy-6A-[[(E)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoyl]Oxymethyl]-2,2,6B,9,9,12A-Hexamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid

📜在 氢氧化钾体系中,化学反应 2.0H,以12.7 Mg的收率获得蜡果杨梅酸 B
参考文献:Endothelin Receptor Antagonist Triterpenoid,Myriceric Acid A,Isolated From Myrica Cerifera,And Structure Activity Relationships Of Its Derivatives.
标题:Endothelin Receptor Antagonist Triterpenoid,Myriceric Acid A,Isolated From Myrica Cerifera,And Structure Activity Relationships Of Its Derivatives.
摘要:作为第一种非肽类内皮素受体拮抗剂,新的三萜类化合物--美洲杜鹃酸a(myiceric Acid A,50-235)(1)是从海梅果(myrica Cerifera)中分离得到的.美洲杜鹃酸a(1)不仅抑制了内皮素-1诱导的细胞质游离ca<2+>浓度的增加(ic50 = 11+/-2 Nm),还抑制了[<125&i]内皮素-1在大鼠主动脉平滑肌细胞中的结合(ki = 66+/-15 Nm).此外,还分离出了两种新的相关三萜类化合物,美洲杜鹃酸c(6)和美洲杜鹃酸d(8).进一步地,对这些天然产物的化学修饰导致合成了硫酸酯衍生物(13,14,15),其对内皮素受体的亲和力提高了1.5到20倍.讨论了美洲杜鹃酸及其衍生物的结构活性关系.
Doi:10.1248/cpb.44.343