CAS: 14924-53-9; Ethyl Cyclobutanecarboxylate

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2-重氮基环戊酮 以 氯仿 用作溶剂,化学反应 0.17H,反应生成环丁烷甲酸乙酯
参考文献:Direct Observation Of .Alpha.-Oxo Ketenes From The Photolysis Of .Alpha.-Diazo .Beta.-Diketones
标题:Direct Observation Of .Alpha.-Oxo Ketenes From The Photolysis Of .Alpha.-Diazo .Beta.-Diketones
摘要:Monitoring By Ir Spectroscopy Of The Broad-Band Irradiation Of The Symmetrically Substituted 2-Diazo-Cyclohexane-1,3-Dione (I 1),3-Diazopentane-2,4-Dione (19),And 4-Diazo-2,2,6,6-Tetramethylheptane-3,5-Dione (24) In Ar Matrices At 12 K Showed The Formation Of 2-Carbonylcyclopentanone (S-Z-12),Acetyl(Methyl)Ketene (S-E-20),And Tert-Butyl(Pivaloyl)Ketene (S-E-25),Respectively,In Less Than 10 Min. On Increasing The Photolysis Time To >3 H,The Alpha-Oxo Ketenes 12,20,And 25 Decarbonylated To The Corresponding Oxocarbenes Which Underwent Wolff Rearrangement To Carbonylcyclobutane (15),Dimethylketene (23),And Di-Tert-Butylketene (28),Respectively. The Reaction Of 2-Carbonylcyclopentanone (12) With Ch3Oh Was Monitored By Ir Spectroscopy. Thus,It Was Found That The Reaction Started At Ca. 100 K And Was Essentially Complete At 140 K,Involving The Initial Formation Of The Enol Form (9) Of Methyl 2-Oxocyclopentanecarboxylate.
Doi:10.1021/jo00044A019

专利信息

专利号:US-11401273-B2
优先权日:2018-11-20
标题:Asymmetric synthesis of Azaspiro compounds
发明人：LELETI RAJENDER REDDY; WAMAN YOGESH; KALLURE PRIYA; BEGUM ZUBEDA; DIVYA THUMBAN; NALIVELA KUMARA SWAMY; VIJAY SAURABH; PARIKH PARANJAY; KOTTURI SHARADSRIKAR; PATEL CHIRAG; NAYAK KRISHNA; BAHAROONI KASIMRAZA; ZALAVADIYA VINKAL
权利人:PIRAMAL PHARMA LTD
摘要:The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.

专利号:US-4436912-A
优先权日:1981-09-08
标题:7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
发明人：WHEELER WILLIAM J
权利人:LILLY CO ELI
摘要:Cephalosporin broad spectrum antibiotics possessing a 7 beta -[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino]acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosporin antibiotics.

专利号:US-2022041609-A1
优先权日:2018-11-20
标题:An improved asymmetric synthesis of azaspiro compounds

专利号:CN-112300020-A
优先权日:2019-11-28
标题:A kind of method for vanadium-catalyzed synthesis of amide derivatives

专利号:US-4430499-A
优先权日:1981-09-08
标题:7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido]cephalosporin antibiotics
发明人：WHEELER WILLIAM J
权利人:LILLY CO ELI
摘要:Cephalosporin broad spectrum antibiotics possessing a 7 beta -[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino)acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosorin antibiotics.

专利号:CN-112300020-B
优先权日:2019-11-28
标题:A kind of method of vanadium catalysis synthesis amide derivative