专利号:WO-2011106986-A1 优先权日:2010-03-02 标题:Inhibitors of hepatitis c virus ns5b polymerase 发明人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO 权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO 摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.
专利号:US-12071388-B2 优先权日:2020-12-24 标 题:Full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds 发明人:YUAN QILIANG; MIAO YONGYI; SHI YONGGEN; ZHANG YIQIANG; CHEN YINHAO; WANG CHAO 权利人:FUJIAN ZHONGXIN FLUORIDE MATERIAL GAOBAO TECH CO LTD; ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD 摘要:A full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds. Aromatic amine and hydrogen fluoride are respectively pumped into thermostats A and B, then flow into micro-channel reactor C for salt forming reaction whose temperature is kept constant; sulfuric acid solution of nitrosylsulfuric acid is pumped into thermostat D; after keeping the temperature constant, the sulfuric acid solution of nitrosylsulfuric acid and salt forming product flowing out from the micro-channel reactor C flow into micro-channel reactor E for diazotization reaction; the obtained product flows into micro-channel reactor F for thermal decomposition reaction, is cooled in cooler G, then enters three-phase separator H for continuous separation, fluorine-containing aromatic hydrocarbon crude product is subjected to continuous alkaline washing, drying and rectification to obtain fluorine-containing aromatic hydrocarbon finished product, and mixture of hydrofluoric acid and sulfuric acid is continuously distilled to obtain hydrogen fluoride and sulfuric acid.
专利号:WO-2009143405-A2 优先权日:2008-05-22 标 题:Synthesis of graphene sheets and nanoparticle composites comprising same
专利号:US-2011186789-A1 优先权日:2008-05-22 标题:Synthesis of graphene sheets and nanoparticle composites comprising same 发明人:SAMULSKI EDWARD T; SI YONGCHAO; DINGEMANS THEO 权利人:UNIV NORTH CAROLINA 摘要:A method for producing isolatable and dispersible graphene sheets, wherein the graphene sheets may be tailored to be soluble in aqueous, non-aqueous or semi-aqueous solutions. The water soluble graphene sheets may be used to produce a metal nanoparticle-graphene composite having a specific surface area that is 20 times greater than aggregated graphene sheets. Graphene sheets that are soluble in organic solvents may be used to make graphene-polymer composites.
专利号:CN-112608212-A 优先权日:2020-12-24 标题 :A kind of fully continuous flow synthesis process of fluorine-containing aromatic compounds
专利号:US-2022204427-A1 优先权日:2020-12-24 标 题:Full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds
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