CAS: 1339022-10-4; (S)-Tert-Butyl 2-(Hydroxymethyl)-2-Methylpyrrolidine-1-Carboxylate

相似化合物

1207754-99-1 317355-81-0 1523541-78-7

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate N-(tert-butoxycarbonyl)-2-methyl-L-proline (S)-1-tert-butyl 2-methyl 2-methylpyrrolidine-1,2-dicarboxylate (S)-2-methylpyrrolidine-2-carboxylic acid(S)-benzyl (7a-methyl-1-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizin-3-yl)(3-methylbut-2-enoyl)carbamate (S)-3-amino-7a-methyl-5,6,7,7a-tetrahydro-1H-pyrrolizin-1-one potassium (S)-7a-methyl-1-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylate (S)-tert-butyl 2-formyl-2-methylpyrrolidine-1-carboxylate

📜(S)-2-甲基脯氨酸置于锂硼氢,氯化亚砜,三乙胺体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 11.25H,反应生成(2S)-2-(羟甲基)-2-甲基吡咯烷-1-羧酸叔丁酯
参考文献:L-脯氨酸衍生的含氮甾体系统:对14-氮杂类固醇的不对称方法†
标题:L-脯氨酸衍生的含氮甾体系统:对14-氮杂类固醇的不对称方法†
摘要:已经描述了在温和的反应条件下使用l-脯氨酸来访问14-氮杂类固醇的有效手性池方法.关键步骤涉及分子内的s N 2'环化反应,以在含氮的甾族结构中在δ9 (11)位置携带不饱和键,以构建关键的c环.为了合成一些新的同类物,还观测到了a环上给电子基团和b环上的氧等杂原子对c环环化倾向的远程电子影响.
Doi:10.1039/c3Ra42272K

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.