CAS: 126798-27-4; 3-Methyl-2-Oxo-1,2-Dihydropyridine-4-Carboxylic Acid

该化合物是一种环环状有机化合物,其特点是四级的芯,其固态酸替代成分为碳oxylic 酸,而三级的甲基组为1,115#注1,这一结构在合成应用中具有多功能,特别是作为制药和农用化学合成的中间体.碳oxylic酸和红心酸的功能都增强了其再活动,有利于在凝聚,循环和衍生反应中使用.其稳定的晶体形式确保了一致的处理和储存.该化合物的界定明确的分子结构使得它对于建造复杂的外循环或改变生物活性分子具有价值,为研究人员提供了一种可靠的药物发现和物质科学应用的建筑块.

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38076-81-2 22282-72-0 1227513-73-6

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3-N-dimethyl-2-methoxyisonicotinanilide

合成工艺路线路线简述

    📜3-N-Dimethyl-2-Methoxyisonicotinanilide置于盐酸体系中,化学反应 7.0H,以86%的收率获得3-甲基-2-氧代-1,2-二氢吡啶-4-甲酸
    参考文献:有机锂及相关试剂在合成中的应用.第7部分.4-甲氧基吡啶啉-和2-甲氧基异烟碱-苯胺的合成和金属化.制备2,3,4-三取代吡啶的有用方法
    标题:有机锂及相关试剂在合成中的应用.第7部分.4-甲氧基吡啶啉-和2-甲氧基异烟碱-苯胺的合成和金属化.制备2,3,4-三取代吡啶的有用方法
    摘要:描述了4-甲氧基吡啶啉-和2-甲氧基异烟酰胺-苯胺的合成和金属化,作为将吡啶甲酸和异烟酸酸区域特异性转化为2,3,4-三取代的吡啶的方法.所得的c 3-烷基化衍生物经历平滑的酸催化转化为相应的吡啶酮.
    Doi:10.1016/s0040-4020(01)89209-7

    海关参考信息

    专利信息


    专利号:US-5846993-A
    优先权日:1992-12-22
    标题:HIV protease inhibitors
    发明人:DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; TATLOCK JOHN H; RODRIGUEZ MICHAEL J
    权利人:AGOURON PHARMA
    摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

    专利号:US-6271235-B1
    优先权日:1992-12-22
    标题:HIV protease inhibitors
    发明人:DRESSMAN BRUCE A; FRITZ JAMES E; KALDOR STEPHEN W; KALISH VINCENT J; REICH SIEGFRIED HEINZ; RODRIGUEZ MICHAEL J; SHEPHERD TIMOTHY A; TATLOCK JOHN H; JUNGHEIM LOUIS NICKOLAUS
    权利人:AGOURON PHARMA
    摘要:HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:10.1016/S0040-4020(01)89209-7
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