CAS: 117194-77-1; 3A-Amino-3A-Deoxy-(2As,3As)-β-Cyclodextrin

该化合物是一种经过修改的环球extrin,在环球extrin结构中的葡萄糖单位的3个位置上,有氨基类替代,这种修改提高了其在水中的溶解性,并能够改善与各种客人分子的互动,使其在医药和生化应用中发挥作用.该化合物保留了乙型环球EXrin的典型循环结构,该结构由7个与阿尔法-1,4-glycosidic 键相连的葡萄糖组成,形成了一种水医学外表和缺水性隐性腔.这一独特的结构使该化合物能够凝聚氢聚合,便利其溶解性和稳定性.氨基组还可以参与各种化学反应,有可能增强该化合物在药物运载系统中的功能.

结构式图片

相似化合物

29390-67-8 1659293-76-1 121916-94-7

物理性质

MSDS等安全信息

上下游产品

β-cyclodextrin-2,3-mannoepoxide A-azido-3A-deoxy-altro-β-cyclodextrin3A-azido-3A-deoxy-altro-β-cyclodextrin 51H77NO37C51H77NO37

合成工艺路线路线简述

    📜β-Cyclodextrin-2,3-Mannoepoxide置于ammonium Hydroxide体系中,化学反应 3.0H,反应生成3A-氨基-3A-脱氧-(2As,3As)-β-环糊精水合物
    参考文献:Synthesis And Chiral Recognition Property Of 3-Acetylamino-3-Deoxy-β-Cyclodextrin
    标题:Synthesis And Chiral Recognition Property Of 3-Acetylamino-3-Deoxy-β-Cyclodextrin
    摘要:单(3-乙酰氨基-3-脱氧)-β-环糊精(4)首先是通过氨对甘露环氧乙烷进行区域选择性开环而制备的.1H-NMR 研究清楚地表明,4 通过形成非对映包合物识别了扁桃酸和 N-乙酰基苯甘氨酸的手性.
    Doi:10.1246/cl.1988.553

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    专利信息


    专利号:US-2011256592-A1
    优先权日:2008-12-12
    标题:Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions
    发明人：BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GULLUKAYA ARZU
    权利人:EUROGENTEC SA
    摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.

    专利号:EP-2373811-A1
    优先权日:2008-12-12
    标题 :Use of cyclodextrins to improve the specificity, sensitivity and yield of nucleic acid amplification reactions
    发明人：BECKERS MARIE-CLAIRE; CRONET PHILIPPE; VITALE ADELINE; COLLETTE ERIC; GUELLUEKAYA ARZU
    权利人:EUROGENTEC SA
    摘要:The invention is directed to methods for in vitro DNA synthesis catalysed by a DNA polymerase using cyclodextrins. The invention also relates to methods, compositions and kits comprising cyclodextrins for the amplification of a nucleic acid. The use of cyclodextrins improves the specificity, sensibility and/or yield of the amplification reaction. The invention is related more particularly to kits, compositions and methods for carrying out PCR reactions comprising a cyclodextrin.

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    合成参考文献

    参考DOI号:10.1021/jo035229m
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