CAS: 10387-13-0; 9,10-Bis(Chloromethyl)Anthracene

该化合物是一种多用途有机化合物,主要用作合成化学的关键中间体,特别是用于制作炭疽衍生物,其活性氯甲基组群能够高效地发挥作用,对于建造聚合物,染料和光活材料等复杂的分子结构很有价值.该化合物的硬性炭疽核心有助于加强稳定性和电子特性,这对光电子应用是有利的.其明确界定的结构还有利于进行受控的修改,支持材料科学和药物的研究.由于其高纯度和一致性,9,10-Bis(氯甲基)乙烷是精确合成和先进化学研究的可靠选择.

英文名称9,10-Bis(Chloromethyl)Anthracene
中文名称9,10-二(氯甲基)蒽
IUPAC名称9,10-bis(chloromethyl)anthracene
其它别名9,10-Di(chloromethyl)anthracene
CAS编号10387-13-0
MFCD编号:MFCD00045388
EINECS号:677-977-0
FDA UNII编号:74QY2YM6ZQ
分子式:C16H12Cl2
分子量:275.172
产品CID: 74726
产品分类有机原料 → 烃类化合物及其衍生物 → 芳香烃

相似结构搜索
产品信息参考;
InChIKey: UOSROERWQJTVNU-UHFFFAOYSA-N
InChI=1S/C16H12Cl2/c17-9-15-11-5-1-2-6-12(11)16(10-18)14-8-4-3-7-13(14)15/h1-8H,9-10H2…
计算化学: 氢键受体数0.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
皮肤腐蚀类别1B
水生慢性毒性类别4
金属腐蚀物类别1
急性毒性类别4(吸入)
急性毒性类别4(经皮)
严重眼损伤类别1
警示词Danger(危险)
危险描述H302 |吞咽有害.
H314 |造成严重皮肤灼伤和眼损伤.
H413 |可能对水生生物造成长期有害影响.
H290 |可能对金属造成腐蚀.
H332 |吸入有害.
H312 |皮肤接触有害.
H318 |造成严重眼损伤.
防范说明P234-P260-P264-P270-P271-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501
危险等级8
UN编号3261
危险品标志Xi
包装等级II
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 9,10-Bis(Chloromethyl)Anthracene 主要起始原料 Formaldehyde And Anthracene
(文献来源)合成步骤主要原料 Formaldehyde 和 Anthracene

聚合甲醛,蒽置于盐酸体系中,用 1,4-二氧六环,水用作溶剂,化学反应 5.0H,以38%的收率获得9,10-二(氯甲基)蒽
参考文献:杂原子辅助聚集诱导的增强发射(aiee)化合物的溶剂变色,可逆色差和自组装效应
标题:杂原子辅助聚集诱导的增强发射(aiee)化合物的溶剂变色,可逆色差和自组装效应
摘要:合成并研究了两种化合物,9,10-双[2-(喹啉基)乙烯基]蒽(bqva)和9,10-双[2-(萘-2-基)乙烯基]蒽(bnva).它们都具有聚集诱导的增强发射(aiee)特性.杂原子辅助的bqva表现出溶剂变色,可逆的变色性质和自组装效应.当增加溶剂极性时,Bqva的绿色溶液变为橙色,荧光发射波长从λ = 527到565 Nm发生红移.值得注意的是,Bqva具有可逆的色差特性,包括机械色差和热色差.所制备的粉末bqva显示绿色荧光(λ Em = 525纳米)和颜色可以变成橙(λ Em= 573Nm).有趣的是,橙色可以在高温下返回.基于这些可逆的色度特性,设计了一种简单方便的可擦除板.与bqva不同,非杂原子辅助的bnva没有清晰的发色过程.X射线衍射,差示扫描量热法,单晶分析和理论计算得出的结果表明,铬化过程取决于bqva中的杂原子.此外,Bqva在不同溶剂中也表现出出色的自组装效果.
Doi:10.1002/chem.201501902

专利信息

专利号:US-10597342-B2
优先权日:2017-03-29
标题 :Method for the synthesis of 9,10-bis(chloromethyl)anthracene
发明人：ORTEGA HIGUERUELO FRANCISCO JOSÃ‰; LANGA DE LA PUENTE FERNANDO
权利人:UNIV CASTILLA LA MANCHA
摘要:The invention relates to a method for the synthesis of 9,10-bis(chloromethyl) anthracene, comprising the mixing of the reagents, anthracene and 1,3,5-trioxane, a phase transfer catalyst selected from the group comprising quarternary ammonium salt and crown ether with hydrochloric acid and acetic acid.

专利号:US-7189864-B2
优先权日:1990-11-19
标题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-2002161234-A1
优先权日:1990-11-19
标题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors