CAS: 96-83-3; 2-(3-Amino-2,4,6-Triiodobenzyl)Butanoic Acid

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CAS号16623-25-9 Alpha-乙基-间氨基苯丙酸盐酸盐 | CAS号5253-02-1 2-乙基-3-(3-硝基苯基)丙烯酸 | CAS号100850-30-4 ethyl 2-[(3-ami...

📜Alpha-乙基-间氨基苯丙酸盐酸盐置于盐酸,一氯化碘体系中,化学反应生成 碘番酸
参考文献:The Preparation Of Some Iodinated Aminophenylalkanoic Acids
标题:The Preparation Of Some Iodinated Aminophenylalkanoic Acids
摘要:
DOI:10.1021/ja01179A048

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-9549995-B2
优先权日:2012-03-26
标 题:Efficient synthesis of ethylenedicysteine-sugar conjugates for imaging and therapy
发明人：YANG DAVID J; YU DONG-FANG
权利人:UNIV TEXAS
摘要:Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-8147805-B2
优先权日:2005-01-05
标题:Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
发明人：YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND
权利人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND; UNIV T EXAS SYSTEM BOARD OF REGENTS
摘要:Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X 1 —Y—X 2 , wherein Y comprises two or more carbohydrate residues covalently attached to one another, X 1 and X 2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X 1 and X 2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

专利号:US-3553260-A
优先权日:1967-05-29
标 题 :Radiopaque derivatives of alpha-phenoxy-phenylacetic acid
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:A - (3 - N-ALKYL-N-ACETYLAMINO-2,4,6-TRIIODOPHENOXY)PHENYLACETIC ACID AND CLOSELY RELATED DERIVATIVES OF THE FORMULA 1,3,5-TRI(I-),2-((R3-PHENYL)-CH(-COOH)-O-),4-(R2-CO- N(-R1)-)BENZENE WHEREIN R1 IS LOWER ALKYL, R2 IS HYDROGEN OR LOWER ALKYL, AND R3 IS HYDROGEN, HALOGEN OR LOWER ALKYL, AND THE PHYSIOLOGICALLY TOLERATED, WATER SOLUBLE METAL OR AMINE SALTS THEREOF ARE RADIOPAQUE, TEND TO ACCUMULATE IN THE GALL BLADDER WHEN APPLIIED ORALLY, AND ARE NON-TOXIC IN EFFECTIVE AMOUNTS. THE CORRESPONDING LOWER ALKYL ESTERS ARE INTERMEDIATES IN THE SYNTHESIS OF THE ACIDS AND SALTS.