1138434-30-6 = 84110-40-7 反应条件:1.1 Reagents: Silica Solvents: Water; Rt 标题:Potassium Methyltrifluoroborate 作者:Molander,Gary A.; Petrillo,Daniel E. 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2016 卷标:1 页码:1-8]
1138434-30-6 = 84110-40-7 反应条件:1.1 Reagents: Silica,Water Solvents: Water; 1 H,Rt 标题:Efficient Hydrolysis Of Organotrifluoroborates Via Silica Gel And Water 作者:Molander,Gary A.; Cavalcanti,Livia N.; Canturk,Belgin; Pan,Po-Shen; Kennedy,Lauren E. 参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(19) 页码:7364-7369]
= 84110-40-7 反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran; Rt -> 40 °C1.2 Reagents: Trimethyl Borate; 40 °C; Overnight,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water 标题:Study On The Synthesis Of Hydrochloride Of 1-(1-Amino-3-Methylbutyl)Borate Pinacol 作者:Zheng,Yongsheng; Guo,Ju; Chen,Dan; Li,Feng; Yang,Yue; Et Al 参考文献:Huaxue Yanjiu Yu Yingyong 日期:2008 卷标:20(12) 页码:1630-1632]
1138434-30-6 = 84110-40-7 反应条件:1.1 Solvents: Water; 1 - 2 H,Rt 标题:Unlocking The Accessibility Of Alkyl Radicals From Boronic Acids Through Solvent-Assisted Organophotoredox Activation 作者:Ranjan,Prabhat; Pillitteri,Serena; Coppola,Guglielmo; Oliva,Monica; Van Der Eycken,Erik V.; Et Al 参考文献:Acs Catalysis 日期:2021 卷标:11(17) 页码:10862-10870]
= 84110-40-7 反应条件:1.1 Solvents: Dichloromethane 标题:Gas Chromatography Of Homologous Esters. Xxxiv. Alkyl Borate And Boronate Esters 作者:Haken,J. K.; Abraham,F. 参考文献:Journal Of Chromatography 日期:1991 卷标:550(1-2) 页码:155-70
三(2-甲基丙基)硼烷置于sodium Hydroxide,Air体系中,化学反应生成 异丁基硼酸 参考文献:The Reactions Of Diborane With Hydrocarbons1 标题:The Reactions Of Diborane With Hydrocarbons1 摘要: DOI:10.1021/ja01186A020
专利信息
专利号:US-10669292-B2 优先权日:2014-05-05 标 题 :Synthesis of boronate salts and uses thereof 发明人:HECKER SCOTT; BOYER SERGE 权利人:REMPEX PHARMACEUTICALS INC 摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.
专利号:US-9862745-B2 优先权日:2004-03-30 标题 :Synthesis of boronic ester and acid compounds 发明人:AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER 权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC 摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
专利号:US-2025163076-A1 优先权日:2022-02-18 标 题 :Synthesis of bruton's tyrosine kinase inhibitors 发明人:TRAN NGOC DUC; XIOURAS CHRISTOS; CLEATOR EDWARD; MATON WILLIAM MARC; RAMMELOO THOMAS JOACHIM LANDEWALD; FERNANDES PHILIPPE; BONGARTZ JEAN-PIERRE A; CAO DUY CHI TRUNG; HORWITZ MATTHEW ALLAN; JUSSEAU XAVIER JEAN-MARIE; LEMAIRE SÉBASTIEN FRANCOIS-EMMANUEL; SCHWEITZER-CHAPUT BERTRAND 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form.
专利号:US-11542283-B2 优先权日:2018-05-28 标题 :Synthesis of peptide borate ester compound and use thereof 发明人:QIN YANRU 权利人:JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO LTD 摘要:Provided are a peptide borate ester compound or a pharmaceutically acceptable salt thereof, a preparation method therefor, and pharmaceutical use thereof. The peptide borate ester compound or pharmaceutically acceptable salt thereof has a structure as shown in Formula (I), and is useful in the preparation of proteasome inhibitors to treat solid tumors and hematoma.
专利号:US-8207337-B2 优先权日:2007-01-29 标 题:Reagent for organic synthesis reaction containing organic triol borate salt 发明人:MIYAURA NORIO; YAMAMOTO YASUNORI 权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD 摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).
专利号:US-8378099-B2 优先权日:1994-10-28 标 题:Boronic ester and acid compounds, synthesis and uses 发明人:ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS 摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 63. 摘要:Hall, D. G.; Zheng, H., Science of Synthesis Knowledge Updates, (2011) 4, 84. 摘要:Kalyani, D.; Desai, L. V., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 758. 摘要:Clark, T. B.; Cho, H. Y., Science of Synthesis: Advances in Organoboron Chemistry towards Organic Synthesis, (2019) 1, 131.