CAS: 79770-24-4; 2,4,6-Triiodo-5-[methyl-[3-Oxo-3-[2,4,6-Triiodo-N-Methyl-3,5-Bis(1,3,4-Trihydroxybutan-2-Ylcarbamoyl)Anilino]Propanoyl]Amino]-1-N,3-N-Bis(1,3,4-Trihydroxybutan-2-yl)Benzene-1,3-Dicarboxamide

上下游产品

2,4,6-triiodo-5-(methylamino)isophthalic acid 2,4,6-triiodo-5-aminoisophthalic acid

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-12269790-B1
优先权日:2022-04-29
标题:Process for the preparation of 2,4,6-triiodophenol derivatives
发明人：BARANYAI ZSOLT; GUIDOLIN NICOL; LAZZARI FEDERICA; UGGERI FULVIO
权利人:BRACCO IMAGING SPA
摘要:The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I 2 and an oxide or a salt of an element of group 11 of the periodic table.

专利号:US-9382194-B2
优先权日:2011-10-31
标 题:Iodination process for the preparation of 3, 5-disubstituted-2, 4, 6-triiodo aromatic amines compounds
发明人：XING HONGDENG; LI LEI; HU ZHIQI
权利人:XING HONGDENG; LI LEI; HU ZHIQI; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:The invention discloses a improved process for the preparation of 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein R 1 and R 2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.

专利号:US-9238615-B2
优先权日:2009-04-21
标 题 :Process for the iodination of aromatic compounds
发明人：CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA
权利人:CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

专利号:US-9193659-B2
优先权日:2008-02-20
标 题 :Process for the iodination of aromatic compounds
发明人：GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO
权利人:GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).

专利号:EP-1498115-A1
优先权日:1997-01-16
标 题:Preparation of particles for inhalation
发明人：EDWARDS DAVID A; HANES JUSTIN; EVORA CARMEN; LANGER ROBERT S; VANBEVER RITA; MINTZES JEFFREY; WANG JUE; CHEN DONGHAO
权利人:MASSACHUSETTS INST TECHNOLOGY; PENN STATE RES FOUND
摘要:Particles incorporating a surfactant and/or a hydrophilic or hydrophobicncomplex of a positively or negatively charged therapeutic agent and a chargednmolecule of opposite charge for drug delivery to the pulmonary system, andnmethods for their synthesis and administration are provided. In a preferrednembodiment, the particles are made of a biodegradable material and have antap density less than 0.4 g/cm 3 and a mass mean diameter between 5 µm andn30 µm, which together yield an aerodynamic diameter of the particles ofnbetween approximately one and three microns. The particles may be formednof biodegradable materials such as biodegradable polymers. For example, thenparticles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymersnthereof. Alternatively, the particles may be formed solely of a therapeutic orndiagnostic agent and a surfactant. Surfactants can be incorporated on thenparticule surface for example by coating the particle after particle formation, ornby incorporating the surfactant in the material forming the particle prior tonformation of the particle. Exemplary surfactants include phosphoglyceridesnsuch as dipalmitoyl phosphatidylcholine (DPPC). The particles can beneffectively aerosolized for administration to the respiratory tract to permitnsystemic or local delivery of wide a variety of therapeutic agents. Formation ofncomplexes of positively or negatively charged therapeutic agents withnmolecules of opposite charge can allow control of the release rate of thenagents into the blood stream following administration.