专利号:US-7459552-B2 优先权日:2003-05-28 标 题:Method for producing cyclic diamine derivative or salt thereof 发明人:SHIBUYA KIMIYUKI; OHGIYA TADAAKI; MIURA TORU 权利人:KOWA CO 摘要:The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: n n(wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.
专利号:US-4791225-A 优先权日:1986-01-20 标题:Halogenobenzoic acid derivatives and their preparation 发明人:IRIKURA TSUTOMU; SUZUE SEIGO; MURAYAMA SATOSHI; HIRAI KEIJI; ISHIZAKI TAKAYOSHI 权利人:KYORIN SEIYAKU KK 摘要:The present invention is concerned with certain novel halogenobenzoic acid derivatives of the following formula, ##STR1## wherein R is a chlorine atom, amino group or hydroxy group, X is a chlorine atom or bromine atom, which are useful intermediates for the synthesis of antibacterial agent.
专利号:US-4788320-A 优先权日:1986-01-20 标题 :Benzoylacetic acid ester derivatives and process for their preparations 发明人:IRIKURA TSUTOMU; SUZUE SEIGO; MURAYAMA SATOSHI; HIRAI KEIJI; ISHIZAKI TAKAYOSHI 权利人:KYORIN SEIYAKU KK 摘要:The present invention is concerned with certain novel benzoylacetic acid ester derivatives (I) which are useful as a intermediates for synthesis of antibacterial agests. ##STR1## wherein R is a lower alkyl group, X is a halogen atom and Y is a chlorine or bromine atom.
专利号:US-2018355099-A1 优先权日:2015-12-09 标题:Fluorinated Benzoxadiazole-Based Donor-Acceptor Polymers for Electronic and Photonic Applications 发明人:YAN HE; ZHAO JINGBO 权利人:UNIV HONG KONG SCI & TECH 摘要:A polymer comprising a repeating unit, which may further comprise one or more repeating units. The present subject matter also relates to a formulation comprising the polymer, and a fullerene, second polymer, or small molecule. The present subject matter further relates to an organic electronic (OE) device comprising a coating or printing ink containing the formulation, where the OE device may be an organic field effect transistor (OFET) device or an organic photovoltaic (OPV) device. The present subject matter also relates to synthesis of monomers, polymers, and the compounds produced therein.
专利号:NO-333799-B1 优先权日:2003-07-07 标 题:Intermediate for the synthesis of 2,4-bis (trifluoroethoxy) pyridine compounds
专利号:US-2008280933-A1 优先权日:2006-07-25 标 题:Benzimidazolyl compounds 发明人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A 权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
[参考文献]: Antonio Carta, Et Al. Novel Substituted Quinoxaline 1,4-Dioxides With In Vitro Antimycobacterial And Anticandida Activity. Eur J Med Chem. 2002 May;37(5):355-66.
合成参考文献
参考文献:10.1055/s-0032-1317782 摘要:Balzarini J, Mikhailopulo I, Konstantinova I, Selezneva O, Fateev I, Balashova T, Kotovskaya S, Baskakova Z, Charushin V, Baranovsky A, Miroshnikov A. Chemo-Enzymatic Synthesis and Biological Evaluation of 5,6-Disubstituted Benzimidazole Ribo- and 2′-Deoxyribonucleosides. Synthesis. 2012 Dec 07;45(02):272–80. doi: 10.1055/s-0032-1317782.