CAS: 78056-39-0; 3,4-Difluoro-6-Nitroaniline

该化合物是含有分子式C6H4F2N2O2的氟芳烃衍生物,其特点是4和5个位置有2个氟原子,2个位置有1个硝基化合物,其独特的替代模式可增强反应性和选择性,使其成为有机合成中有价值的中间体,特别是制药和农用化学品.氟和硝基化合物的电子抽取效应有助于其用于核循环替代和组合反应.在标准条件下,高纯度和稳定性可确保研究和工业应用的一贯性.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号2105-61-5 2,4,5-三氟硝基苯 | CAS号458-11-7 3',4'-二氟乙酰苯胺 | CAS号329939-78-8 4,5-Difluoro-2-... | CAS号1662-21-1 4,5-二氟-2-硝基乙酰苯胺 | CAS号3863-11-4 3,4-二氟苯胺 | CAS号216883-16-8 4-fluoro-5-morp... | CAS号78581-99-4 5,6-二氟苯并咪唑 | CAS号76179-40-3 4,5-二氟苯-1,2-二胺 | CAS号125163-12-4 4-氟-5-甲氧基-2-硝基苯胺 | CAS号171111-70-9 5,6-二氟苯并[c][1,2... | CAS号174468-55-4 4-氟-5-(4-甲基哌嗪-1... | CAS号958863-36-0 2-(二乙氧基甲基)-5,6-...

合成工艺路线路线简述

    3',4'-二氟乙酰苯胺置于硝酸体系中,用 溶剂黄146 作为反应溶剂,化学反应 4.0H,以24%的收率获得产物4,5-二氟-2-硝基苯胺
    参考文献:通过苯胺的氧化和芳基叠氮化物的热环化合成新型氟苯并呋喃
    标题:通过苯胺的氧化和芳基叠氮化物的热环化合成新型氟苯并呋喃
    摘要:提出了通过氟苯胺的氧化和氟芳基叠氮化物的热环化反应合成几种氟苯并呋喃的方法.NMR数据证明,本研究中制备的氟苯并呋喃具有互变异构现象.苯并呋喃恶烷一般具有生物活性,是用于制备具有重要药学应用的几种化合物的合成中间体.
    DOI:10.1016/s0022-1139(03)00011-3

    专利信息


    专利号:US-7459552-B2
    优先权日:2003-05-28
    标 题:Method for producing cyclic diamine derivative or salt thereof
    发明人:SHIBUYA KIMIYUKI; OHGIYA TADAAKI; MIURA TORU
    权利人:KOWA CO
    摘要:The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: n n(wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.

    专利号:US-4791225-A
    优先权日:1986-01-20
    标题:Halogenobenzoic acid derivatives and their preparation
    发明人:IRIKURA TSUTOMU; SUZUE SEIGO; MURAYAMA SATOSHI; HIRAI KEIJI; ISHIZAKI TAKAYOSHI
    权利人:KYORIN SEIYAKU KK
    摘要:The present invention is concerned with certain novel halogenobenzoic acid derivatives of the following formula, ##STR1## wherein R is a chlorine atom, amino group or hydroxy group, X is a chlorine atom or bromine atom, which are useful intermediates for the synthesis of antibacterial agent.

    专利号:US-4788320-A
    优先权日:1986-01-20
    标题 :Benzoylacetic acid ester derivatives and process for their preparations
    发明人:IRIKURA TSUTOMU; SUZUE SEIGO; MURAYAMA SATOSHI; HIRAI KEIJI; ISHIZAKI TAKAYOSHI
    权利人:KYORIN SEIYAKU KK
    摘要:The present invention is concerned with certain novel benzoylacetic acid ester derivatives (I) which are useful as a intermediates for synthesis of antibacterial agests. ##STR1## wherein R is a lower alkyl group, X is a halogen atom and Y is a chlorine or bromine atom.

    专利号:US-2018355099-A1
    优先权日:2015-12-09
    标题:Fluorinated Benzoxadiazole-Based Donor-Acceptor Polymers for Electronic and Photonic Applications
    发明人:YAN HE; ZHAO JINGBO
    权利人:UNIV HONG KONG SCI & TECH
    摘要:A polymer comprising a repeating unit, which may further comprise one or more repeating units. The present subject matter also relates to a formulation comprising the polymer, and a fullerene, second polymer, or small molecule. The present subject matter further relates to an organic electronic (OE) device comprising a coating or printing ink containing the formulation, where the OE device may be an organic field effect transistor (OFET) device or an organic photovoltaic (OPV) device. The present subject matter also relates to synthesis of monomers, polymers, and the compounds produced therein.

    专利号:NO-333799-B1
    优先权日:2003-07-07
    标 题:Intermediate for the synthesis of 2,4-bis (trifluoroethoxy) pyridine compounds

    专利号:US-2008280933-A1
    优先权日:2006-07-25
    标 题:Benzimidazolyl compounds
    发明人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
    权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Antonio Carta, Et Al. Novel Substituted Quinoxaline 1,4-Dioxides With In Vitro Antimycobacterial And Anticandida Activity. Eur J Med Chem. 2002 May;37(5):355-66.

    合成参考文献


    参考文献:10.1055/s-0032-1317782
    摘要:Balzarini J, Mikhailopulo I, Konstantinova I, Selezneva O, Fateev I, Balashova T, Kotovskaya S, Baskakova Z, Charushin V, Baranovsky A, Miroshnikov A. Chemo-Enzymatic Synthesis and Biological Evaluation of 5,6-Disubstituted Benzimidazole Ribo- and 2′-Deoxyribonucleosides. Synthesis. 2012 Dec 07;45(02):272–80. doi: 10.1055/s-0032-1317782.
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