CAS: 75-23-0; Ethylamine Trifluoroborane

专利信息

专利号:US-4310467-A
优先权日:1980-10-22
标题:Process and intermediates for the synthesis of vitamin D3 metabolites
发明人：BATCHO ANDREW D; BERGER JR DONALD E; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D 3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D 3 metabolites.

专利号:US-11976081-B2
优先权日:2019-04-26
标题 :Intermediate of eribulin and synthesis method and use thereof
发明人：XU WEIPING
权利人:BEIJING TIENYI LUFU PHARMATECH CO LTD
摘要:An intermediate compound is prepared and used for the synthesis of halichondrin B, eribulin or an analog thereof, particularly a structural fragment C27-C35 thereof. The starting materials of the synthetic route are readily available, and the optical purity of the starting materials can be ensured, so that the optical purity of the structural fragment C27-C35 in halichondrin B, eribulin or the analog thereof is ensured. Steps for constructing a chiral center of the structural fragment C27-C35 feature higher diastereoselectivity and yield, in particular preparation methods of compounds of formulae (X), (XI), (XVI) and (XV). By-products of partial reactions can be removed only by recrystallization, which results in easy purification and significant reduce in cost.

专利号:EP-0050325-B1
优先权日:1980-10-22
标题 :Process for the preparation of intermediates in the synthesis of vitamin-d3 metabolites, and intermediates

专利号:EP-0050325-A2
优先权日:1980-10-22
标题:Process for the preparation of intermediates in the synthesis of vitamin-D3 metabolites, and intermediates

专利号:RU-2137763-C1
优先权日:1993-07-06
标题 :Derivatives of (1-phenyl-1-heterocyclyl)alkane, method of their synthesis, pharmaceutical preparation showing neuroprotective effect in brain ischemia, method of treatment of patients with hypoxic and asphyxic brain damages

专利号:EP-3925948-B1
优先权日:2019-04-26
标题:Intermediate of eribulin, synthesis method therefor and use thereof