2-氯-5-硝基苯甲腈置于sodium Hydroxide,双氧水,溴体系中,化学反应生成 2-氯-5-硝基苯胺 参考文献:Blanksma,Recueil Des Travaux Chimiques Des Pays-Bas,1946,Vol. 65,P. 207,210 标题:Blanksma,Recueil Des Travaux Chimiques Des Pays-Bas,1946,Vol. 65,P. 207,210
专利号:US-7658868-B2 优先权日:2002-03-20 标 题 :Molecular actuators, and methods of use thereof 发明人:ANQUETIL PATRICK A; HUNTER IAN W; MADDEN JOHN D; MADDEN PETER G; PULLEN ANTHONY E; SWAGER TIMOTHY M; XU BING; YU HSIAO-HUA 权利人:MASSACHUSETTS INST TECHNOLOGY; US NAVY 摘要:The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from Ï€-Ï€ stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators.
专利号:US-2016194279-A1 优先权日:2012-12-09 标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas 发明人:CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.
专利号:RU-2060994-C1 优先权日:1989-09-08 标 题 :Method of synthesis of aryltriazoline
专利号:RU-2070880-C1 优先权日:1994-04-08 标题 :Method of synthesis of 2-chloro-5-[$$$-(2',4'-di-tert-amylphenoxy)-butyroylamino]-anilide of pivaloylacetic acid
专利号:US-5105012-A 优先权日:1989-03-24 标题 :Catalytic reduction of dinitrobenzenes using a noble metal catalyst and iron or iron salts 发明人:THEODORIDIS GEORGE 权利人:FMC CORP 摘要:There is provided an improved process for the reduction of optionally substituted dinitrobenzenes to the corresponding nitroanilines with high yields which comprises contacting the dinitrobenzene with hydrogen in an acidic medium in the presence of a catalytic amount of a combination of a noble metal hydrogenation catalyst, and iron or an iron salt. Isomer specific reductions may be achieved with those compounds containing suitable directing substituents. The 2-halo-5-nitroanilines which may be produced in this process may be converted via a multi-step synthesis to useful 1-aryl-4-substituted 1,4-dihydro-5H-tetrazol-5-one herbicides.
专利号:US-11801242-B2 优先权日:2018-10-09 标 题:Compositions and methods for adjuvant cancer therapeutics 发明人:ZHOU PEI; HONG JIYONG 权利人:UNIV DUKE 摘要:This invention relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to translesion synthesis (TLS) pathway. More particularly, this disclosure relates to small molecule inhibitors of TLS, methods of inhibiting TLS pathway with these compounds, and methods of treating diseases related to the TLS pathway.
[参考文献]: Tien D Ho, Et Al. Determination Of Trace Level Genotoxic Impurities In Small Molecule Drug Substances Using Conventional Headspace Gas Chromatography With Contemporary Ionic Liquid Diluents And Electron Capture Detection. J Chromatogr A. 2014 Sep 26:1361:217-28.
合成参考文献
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