CAS: 53943-88-7; 2-(2-((2-Ethoxy-2-Oxoethyl)Thio)Ethyl)Thiazolidine-4-Carboxylic Acid

该化合物是一种诱变剂和抗氧化剂,主要用于呼吸道治疗,以管理慢性阻塞性肺病(COPD)和支气管炎,其机制包括打破粘结蛋白中的脱硫结合,降低粘度,改善排污情况. 此外, 莱托斯坦因表现出自由的激进清扫特性,减轻肺组织中的氧化压力. 化合物的特征是其双作用效果,将粘合和抗炎效应与有利的安全特征相结合. 它经常通过口服或吸入进行,表现出良好的生物利用率和低系统毒性. 莱托斯坦因的稳定性和与标准呼吸道疗法的兼容性使得它成为长期管理呼吸道状况的可靠选择.

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    专利信息


    专利号:US-2014378538-A1
    优先权日:2011-12-14
    标 题:Methods of responding to a biothreat
    发明人:BANCEL STEPHANE
    权利人:MODERMA THERAPEUTICS INC
    摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

    专利号:US-9790531-B2
    优先权日:2012-08-14
    标 题 :Enzymes and polymerases for the synthesis of RNA
    发明人:WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
    权利人:MODERNATX INC
    摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

    专利号:US-2024002331-A1
    优先权日:2022-06-08
    标 题 :Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
    发明人:ALI MIR; BOESCH AUSTIN WAYNE; DRUMMOND DARYL CLARK; KUHLMAN WILLIAM; NIELSEN ULRIK
    权利人:TIDAL THERAPEUTICS INC
    摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

    专利号:US-2025205169-A1
    优先权日:2023-12-13
    标 题:Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
    发明人:ALI MIR
    权利人:TIDAL THERAPEUTICS INC
    摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

    专利号:US-2015211039-A1
    优先权日:2012-08-14
    标题:Enzymes and polymerases for the synthesis of rna

    专利号:WO-2014028429-A2
    优先权日:2012-08-14
    标 题 :Enzymes and polymerases for the synthesis of rna

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Gachon F, Nicolas C, Maurizis JC, Verny M, Chabard JL, Faurie M, Gaillard G. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988 Nov- Dec;16(6):853-7. Spec No
    3:243-9. 38(4):167-84. Italian. 69(11):842-9. 105(2):109-18. Italian. 879(25):2554-60. doi: 10.1016/j.jchromb.2011.07.011. Epub 2011 Jul 18. 17(3):76-80. doi: 10.1007/BF01875435. 54(29-32):983-6. French. 116(2):121-9. Italian. 41(10):515-20. Italian. 86(3):170-5. doi: 10.1136/adc.86.3.170.
    12: Macquet V, Ficheroulle X, Ta Van P, Peltier M. Un apport nouveau dans le traitement des broncho-pneumopathies chroniques: la létostéine [A new contribution to the treatment of chronic bronchopneumopathies: letosteine]. Lille Med. 1979 Nov;24(9):735-8. French. 38(3):105-12. Italian. 116(3):179-93. Italian. 34(3):661-9. doi: 10.1016/j.jpba.2003.11.003. 99(12):1477-84. doi: 10.1016/j.rmed.2005.09.039. 6(5):415-23. 85(2):971-81. doi: 10.1016/S0006-3495(03)74536-6.

    合成参考文献


    参考文献:10.1007/bf03256664
    摘要:Poole PJ, Black PN. Preventing exacerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents. Am J Respir Med. 2003;2(5):367–70. doi: 10.1007/bf03256664.
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