CAS: 501-00-8; 2-(3-Fluorophenyl)Acetonitrile

上下游产品

CAS号773837-37-9 sodium cyanide | CAS号456-41-7 3-氟苄溴 | CAS号352-70-5 3-氟甲苯 | CAS号1000370-26-2 methanesulfonic... | CAS号143-33-9 氰化钠 | CAS号456-42-8 间氟氯苄 | CAS号140-29-4 苯乙腈 | CAS号151-50-8 氰化钾 | CAS号462-06-6 氟苯 | CAS号107-14-2 氯乙腈 | CAS号404-70-6 3-氟苯乙胺 | CAS号142121-94-6 2-((叔丁氧基羰基)(3-氟... | CAS号458-04-8 间氟苯乙酰氯间氟苯乙酰氯 | CAS号3456-75-5 5-氟-2-硝基苯乙腈 | CAS号331-25-9 3-氟苯乙酸 | CAS号7292-74-2 氨基-(3-氟苯基)乙酸 | CAS号214262-91-6 1-(3-氟苯基)环己腈 | CAS号214262-98-3 1-(3-氟苯基)环己烷羧酸 | CAS号1737-19-5 3-氟苯基丙酮 | CAS号29419-15-6 7-氟-3,4-二氢-1H-萘-2-酮

3,β,β-Trifluorostyrol置于ammonium Hydroxide体系中,用 乙腈 作为反应溶剂,化学反应 24.0H,以77%的收率获得产物3-氟苯乙腈
参考文献:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
标题:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
摘要:开发了一种可扩展的偕二氟烯烃氰化为(杂)芳基乙腈衍生物的方法.该策略具有反应条件温和,产率高,底物范围广,官能团耐受性广等特点.值得注意的是,在该反应中,氨水为"cn"试剂提供了"n"源,并且完全避免使用有毒的氰化试剂或金属催化剂.因此,我们为芳基乙腈的合成提供了一种绿色替代方法.
DOI:10.1021/acs.Orglett.1C04336

专利信息

专利号:US-9828336-B2
优先权日:2012-02-17
标题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
发明人：MONIZ GEORGE ANTHONY; WILCOXEN ANNIE ZHU; BENAYOUD FARID; TANAKA TOSHIAKI; SORIMACHI KEIICHI
权利人:EISAI R&D MAN CO LTD
摘要:The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:CN-104114524-B
优先权日:2012-02-17
标 题 :Methods and compounds for the synthesis of orexin-2 receptor antagonists

专利号:CA-2861493-C
优先权日:2012-02-17
标题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

专利号:US-9416109-B2
优先权日:2012-02-17
标 题:Methods and compounds useful in the synthesis of orexin-2 receptor antagonists

专利号:US-2016318858-A1
优先权日:2012-02-17
标题 :Methods and compounds useful in the synthesis of orexin-2 receptor antagonists