CAS: 4414-88-4; (2-Benzimidazolyl)Acetonitrile

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2-(1H-1,3-Benzimidazol-2-yl)-2-(Tetrahydro-2-Furanyliden)Acetonitrile置于四氢吡咯体系中,用 异丙醇 作为反应溶剂,以87%的收率获得产物2-氰甲基苯并咪唑
参考文献:Reaction Of 2-Hetaryl-2-(Tetrahydro-2-Furanylidene)Acetonitriles With Aldehydes
标题:Reaction Of 2-Hetaryl-2-(Tetrahydro-2-Furanylidene)Acetonitriles With Aldehydes
摘要:The Reaction Of 2-Hetaryl-2-(Tetrahydro-2-Furanylidene)Acetonitriles With A Electrophilic Reagent (Anisaldehyde) Was Studied. It Was Shown That Condensation Of The Latter With 2-(4-Oxo-3,4-Dihydro-2-Quinazolyl)-And 2-(1H-Benzo[d]Imidazol-2-yl)-2-(Tetrahydro-2-Furanylidene) Acetonitriles In The Presence Of Secondary Amines Or Acids Takes Place With Elimination Of The Furan Fragment And The Formation Of 3-Aryl-2-(4-Oxo-3,4-Dihydro-2-Quinazolinyl)-And 2-(1H-Benzo[d] Imidazol-2-yl)Acrylonitriles.
DOI:10.1007/s10593-010-0604-0

专利信息

专利号:US-4152440-A
优先权日:1975-11-13
标题:Novel derivatives of imidazole, and pharmaceutical compositions containing them
发明人：GEBERT ULRICH; MUSIL JOSEF; WEBER ROLF-ORTWIN
权利人:HOECHST AG
摘要:A compound of one of formulae (I) and (II) (of formula sheet) wherein n R 1 represents a radical selected from the group consisting of hydrogen alkyl containing up to 6 carbon atoms and being unsubstituted or substituted by at least one of the groups alkoxy and phenylalkoxy containing up to 4 carbon atoms in the alkoxy moiety; aryl or aralkyl each containing from 1 to 4 carbon atoms in the alkyl moiety and being unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy and haloalkyl containing up to 4 carbon atoms, halogen and nitro; a 5- or 6-membered heteroaromatic ring containing up to 2 hetero atoms chosen from O,N and S, at most one of which is different from nitrogen; an alkyl group containing from 1 to 4 carbon atoms substituted by such a heteroaromatic ring; n R 2 and R 3 , which are the same or different, each represents a hydrogen atom or, alkyl containing up to 4 carbon atoms and being unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy and haloalkyl containing up to 4 carbon atoms, halogen and nitro; taken together R 2 and R 3 alternatively represent a --CHâ•?CH--CHâ•?CH-- group which is unsubstituted or substituted by a substituent selected from the group consisting of alkyl, alkoxy and haloalkyl, each containing up to 4 carbon atoms, halogen and nitro; n R 4 is selected from the group consisting of hydrogen alkyl, aryl and aralkyl containing up to 4 carbon atoms in each alkyl moiety; and n A represents a single bond or alkylene containing from 1 to 6 carbon atoms; with the proviso that R 1 is other than a hydrogen atom or methyl group when A represents a single bond and R 2 and R 3 taken together represent an unsubstituted --CHâ•?CH--CHâ•?CH-- group; physiologically acceptable salts thereof, a synthesis therefor and a pharmaceutical composition cotaining it.

专利号:US-9580409-B2
优先权日:2011-11-07
标 题:Modulators of opioid receptors and methods of use thereof
发明人：MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:CN-111875591-B
优先权日:2020-08-31
标题:Method for catalytic synthesis of drug intermediate 3-benzo [ d ] imidazole benzopyrone derivative

专利号:US-2005113397-A1
优先权日:2002-01-31
标题:Imidazo[1,2-a]pyridine derivative
发明人：TAKEMURA MAKOTO; TAKAHASHI HISASHI; KAWAKAMI KATSUHIRO; TAKESHITA HIROSHI; KIMURA YOUICHI; WATANABE JUN; SUGIMOTO YUICHI; KITAMURA AKIHIRO; NAKAJIMA RYOHEI; KANAI KAZUO; FUJISAWA TETSUNORI
摘要:A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

专利号:CN-108383880-B
优先权日:2018-05-07
标题 :Coumarin-platinum (II) complexes targeting drug-resistant strains of ovarian cancer and their synthesis methods and applications