CAS: 403-33-8; Methyl 4-Fluorobenzoate

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CAS号67-56-1 甲醇 | CAS号459-56-3 对氟苯甲醇 | CAS号459-57-4 对氟苯甲醛 | CAS号456-22-4 对氟苯甲酸 | CAS号201230-82-2 carbon monoxide | CAS号460-00-4 对氟溴苯 | CAS号107-06-2 1,2-二氯乙烷 | CAS号99768-12-4 4-甲酯基苯硼酸 | CAS号350-40-3 4-氟-α-甲基苯乙烯 | CAS号403-43-0 对氟苯甲酰氯 | CAS号49742-56-5 4’-甲基[1,1’-联苯]-... | CAS号354813-14-2 4-(4-甲基哌嗪)苯甲酸甲酯 | CAS号41421-13-0 5-(4-氟苯基)-1,3,4... | CAS号459-56-3 对氟苯甲醇 | CAS号391-92-4 5-氟-2-羟基苯甲酸甲酯 | CAS号392-04-1 4-氟水杨酸甲酯 | CAS号379-57-7 4,4',4''-三氟三苯甲醇 | CAS号456-06-4 4-氟苯甲酰肼 | CAS号17797-10-3 2-(4-氟苯基)-2-丙胺 | CAS号217661-99-9 1-(4-Fluorophen...

4-Fluoro-N-Methoxybenzamide置于n-溴代丁二酰亚胺(Nbs)体系中,用 甲苯 作为反应溶剂,化学反应 1.0H,以50%的收率获得产物对氟苯甲酸甲酯
参考文献:通过串联nbs介导的氧化同质偶联和热脱氮作用将n-烷氧基酰胺直接转化为羧酸酯
标题:通过串联nbs介导的氧化同质偶联和热脱氮作用将n-烷氧基酰胺直接转化为羧酸酯
摘要:发现在甲苯中用nbs处理n-烷氧基酰胺可以方便地得到相应的羧酸酯,包括带有大体积或长链取代基的那些羧酸酯,令人满意的至优异的产率.该方法不仅代表通过氧化均偶联和随后的热脱氮将烷氧基酰胺部分直接转化为羧酸酯官能团的方便且经济的方法,而且还促进了位阻羧酸酯的合成.
DOI:10.1021/jo401435V

专利信息

专利号:US-2025222120-A1
优先权日:2024-01-09
标题 :Synthesis of novel small molecule carm1 degraders, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XU WEI; XIE HAIBO; BACABAC MEGAN
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are CARM1 PROTACs comprising a binding molecule of CARM1 with an optimized linker attached to an E3 ubiquitin ligase ligand that recruits the E3 ubiquitin ligase to CARM1. The PROTACs find use, e.g., for selectively targeted degradation of CARM1 protein in cancer cells. Also provided herein are compositions comprising the PROTACs, as well as methods of using the PROTACs.

专利号:US-2023174496-A1
优先权日:2020-05-06
标 题:Synthesis of Vinylic Protected Alcohol Intermediates

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:WO-2021225823-A1
优先权日:2020-05-06
标 题:Synthesis of vinylic protected alcohol intermediates

专利号:US-5532408-A
优先权日:1992-10-05
标 题 :α-chain-modified isocarbacyclins and process for the production thereof
发明人：KOGA MASAHIRO; TANAKA TOSHIO; FUJII TAKAO; MASEGI TSUKIO
权利人:TEIJIN LTD
摘要:PCT No. pct/jp93/01407 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 1, 1993 PCT Pub. No. wo94/07838 PCT Pub. Date Apr. 14, 1995.Provided are alpha -chain-modified isocarbacyclins of which the alpha -chain is modified with a phenylene group, a cycloalkylene group or a thiophendiyl group, and these alpha -chain-modified isocarbacyclins show the activity for inhibiting the DNA synthesis of human smooth muscle cell and are expected to be capable of inhibiting the hypertrophy of a blood vessel.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.