CAS: 39392-62-6; β-L-Allopyranose

该化合物是一种稀有的糖,是一种D-allose的缩印,被归类为Aldohexose.它是分子式C6H12O6的单沙酸,其分子式为C6H12O6, 具有六碳脊柱和多氢氧基(OH)组,有助于其在水中的溶解性.B-L-allose以其甜味和潜在的健康利益而著称,包括其在代谢过程中的作用及其低糖溶性指数,使它成为用于食品中减少糖摄入的候选物.该化合物以循环形式存在,主要作为一种烟花,可以经受典型的糖的化学反应,例如氧化和减少.其独特的结构使其能够与酶和受体发生不同互动,而后者与可能影响其生物活动的更多普通糖不同.B-L-L-allose对研究其在制药和功能食品中的潜在应用感兴趣,尽管它比其D-异构体对应物少见.

结构式图片

合成工艺路线路线简述

    📜Methyl (1R,4As,5S,6R,7R,7Ar)-6-Benzoyloxy-5-Hydroxy-7-Methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]-1,4A,5,6,7,7A-Hexahydrocyclopenta[c]Pyran-4-Carboxylate,Methyl (1R,4As,5S,6R,7R,7Ar)-5,6-Dibenzoyloxy-7-Methyl-1-[(2S,3R,4S,5R,6R)-3,4,5-Triacetyloxy-6-(Acetyloxymethyl)Oxan-2-Yl]-1,4A,5,6,7,7A-Hexahydrocyclopenta[c]Pyran-4-Carboxylate,Methyl (1R,4As,6S,7R,7Ar)-6-Benzoyloxy-7-Methyl-1-[(2S,3R,4S,5R,6R)-3,4,5-Triacetyloxy-6-(Acetyloxymethyl)Oxan-2-Yl]-1,4A,5,6,7,7A-Hexahydrocyclopenta[c]Pyran-4-Carboxylate,硫酸 反应生成2,5-二甲基-3-呋喃甲酰氯
    参考文献:Srivastava,Vandita;Rathore,Anita;Mashhood,Ali Syed;Tandon,J. S.,J. Natur. Prod.,53,(1990) N,C. 303-308
    标题:Srivastava,Vandita;Rathore,Anita;Mashhood,Ali Syed;Tandon,J. S.,J. Natur. Prod.,53,(1990) N,C. 303-308

    海关参考信息

    专利信息


    专利号:US-2022395800-A1
    优先权日:2019-11-04
    标题:Device for automated synthesis of oligo- and polysaccharides
    发明人:SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
    权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
    摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

    专利号:EP-3835306-A1
    优先权日:2019-12-13
    标题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to a method for synthesizing oligo- and polysaccharides using microwave radiation, in particular to a method and a device for automated synthesis of oligo- and polysaccharides.

    专利号:US-2022387957-A1
    优先权日:2019-11-04
    标 题 :Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase

    专利号:US-11772063-B2
    优先权日:2018-12-18
    标 题:Method and device for producing saccharides and saccharide arrays
    发明人:LÖFFLER FELIX; MENDE MARCO; EICKELMANN STEPHAN; SEEBERGER PETER H; TSOUKA ALEXANDRA; HEIDEPRIEM JASMIN; PARIS GRIGORI
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

    专利号:EP-4045182-A1
    优先权日:2019-11-04
    标 题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase

    专利号:EP-3815778-A1
    优先权日:2019-11-04
    标 题:Device for rapid automated synthesis of oligo- and polysaccharides

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Device For Automated Synthesis Of Oligo- And Polysaccharides
    摘要:The Present Invention Generally Relates To Automated Synthesis Technology, And More Particularly, To A Device And Method For Automated Synthesis Of Oligo- And Polysaccharides On A Solid Support. In Particular The Present Invention Relates To A Device For Automated Synthesis Of Oligo- And Polysaccharides On A Solid Support Comprising A Reaction Vessel, A Reagent Storing Component, A Reagent Delivery System, A Cooling Device For Cooling Reaction Vessel, And A Pre-Cooling Device For Pre-Cooling The Reagents To Be Supplied.

    合成参考文献


    参考文献:10.1021/acs.jmedchem.0c01578
    摘要:Ito S, Senoo A, Nagatoishi S, Ohue M, Yamamoto M, Tsumoto K, Wakui N. Structural Basis for the Binding Mechanism of Human Serum Albumin Complexed with Cyclic Peptide Dalbavancin. J Med Chem. 2020 Nov 25;63(22):14045–53. doi: 10.1021/acs.jmedchem.0c01578.
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