CAS: 390-64-7; 3,3-Diphenyl-N-(1-Phenylpropan-2-yl)Propan-1-Amine

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CAS号2286-54-6 3,3-二苯基丙腈 | CAS号60-15-1 1-苯基-2-丙胺 | CAS号29648-95-1 (3-chloro-1-phe... | CAS号1049-27-0 3,3-diphenyl-N-...

📜Tert-Butyl (3,3-Diphenylpropyl)Carbamate置于三乙酰氧基硼氢化钠,溶剂黄146,三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 41.0H,反应生成普尼拉明
参考文献:通过脱羧自由基-极性交叉选择性合成官能化直链脂肪族伯胺
标题:通过脱羧自由基-极性交叉选择性合成官能化直链脂肪族伯胺
摘要:脂肪族伯胺至关重要,每年至少需要数百万吨.因此,人们对寻找新的合成化学路线产生了浓厚的兴趣.此外,为了符合可持续性要求,高度优先考虑使用廉价原料的合成路线.在这方面,由于烯烃的广泛可用性和较低的价格,加氢氨基烷基化(haa)反应是非常理想的.尽管光氧化还原催化已知用于合成胺,但直链脂肪胺的合成主要限于加氢氨甲基化(ham)反应,并且从未应用于长链直链脂肪伯胺的合成.考虑到这一点,通过使用脱羧自由基-极性交叉工艺证明了官能化直链脂肪伯胺的合成,该方法以优异的收率产生了多种官能化直链脂肪胺.该方法的优势通过现有药物的合成和复杂药物的后期转化得到证明,并通过详细的机理研究进行了阐述.
Doi:10.1039/d3Gc03187J

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-10561681-B2
优先权日:2016-07-21
标题 :Antimetastatic 2H-selenopheno[3,2-h]chromenes, synthesis thereof, and methods of using same agents
发明人：ARSENJANS PAVELS; VASILJEVA JELENA; DOMRACHEVA ILONA; SHESTAKOVA IRINA; KALVINS IVARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prevention of primary cancer and its metastasis by administration of such substances.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-10105348-B2
优先权日:2015-08-03
标题:Use of 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide in the treatment of seizures
发明人：ZVEJNIECE LIGA; DAMBROVA MAIJA; SVALBE BAIBA; VAVERS EDIJS; KALVINS IVARS; VEINBERGS GRIGORIJS; STONANS ILMARS; MISANE ILGA; VORONA MAKSIMS; CERNOBROVIJS ALEKSANDRS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:Use of 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide or its pharmaceutically acceptable salt in manufacture of a medicament for prophylaxis and treatment of seizure.

专利号:KR-101513003-B1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications