CAS: 369-26-6; Methyl 3-Amino-4-Fluorobenzoate

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CAS号329-59-9 4-氟-3-硝基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号2365-85-7 3-氨基-4-氟苯甲酸 | CAS号456-22-4 对氟苯甲酸 | CAS号1007-16-5 3-溴-4-氟苯甲酸 | CAS号82702-31-6 3-溴-4-氟苯甲酸甲酯 | CAS号453-71-4 4-氟-3-硝基苯甲酸 | CAS号99-05-8 间氨基苯甲酸 | CAS号77-78-1 硫酸二甲酯 | CAS号125568-76-5 methyl 3-azido-...

3-溴-4-氟苯甲酸置于tris(Dibenzylideneacetone)Dipalladium(0) Chloroform Complex,硫酸,Caesium Carbonate,4,5-双二苯基膦-9,9-二甲基氧杂蒽,三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,反应生成3-氨基-4-氟苯羧酸甲酯
参考文献:Discovery Of Dabrafenib: A Selective Inhibitor Of Raf Kinases With Antitumor Activity Against B-Raf-Driven Tumors
标题:Discovery Of Dabrafenib: A Selective Inhibitor Of Raf Kinases With Antitumor Activity Against B-Raf-Driven Tumors
摘要:Hyperactive Signaling Of The Map Kinase Pathway Resulting From The Constitutively Active B-Raf(V600E) Mutated Enzyme Has Been Observed In A Number Of Human Tumors,Including Melanomas. Herein We Report The Discovery And Biological Evaluation Of Gsk2118436,A Selective Inhibitor Of Raf Kinases With Potent In Vitro Activity In Oncogenic B-Raf-Driven Melanoma And Colorectal Carcinoma Cells And Robust In Vivo Antitumor And Pharmacodynamic Activity In Mouse Models Of B-Raf(V600E) Human Melanoma. Gsk2118436 Was Identified As A Development Candidate,And Early Clinical Results Have Shown Significant Activity In Patients With B-Raf Mutant Melanoma.
Doi:10.1021/ml4000063