CAS: 34824-58-3; 2-(2-Bromophenyl)-1,3-Dioxolane

该化合物是一种溴化芳烃化合物,其特点是1,3-二氧醇保护组,通常用于合成有机化学,其主要优点包括在基本和核循环条件下保持稳定,使其成为有选择地使芳香系统功能化的宝贵中间体.在圆形位置上的溴分质允许通过交叉反应进一步衍生,如铃木或Heck交接,而二氧醇组则为碳基功能提供保护.该化合物在多步组合中特别有用,提供受控的再活动以及与一系列试剂的兼容性.其定义明确的结构确保复杂变异的再生性,支持药物和精细化学合成的应用.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号107-21-1 乙二醇 | CAS号6630-33-7 2-溴苯甲醛 | CAS号7732-18-5 水 | CAS号144-55-8 碳酸氢钠 | CAS号107-07-3 2-氯乙醇 | CAS号7381-30-8 1,2-双(三甲基硅氧基)乙烷 | CAS号95-46-5 2-溴甲苯 | CAS号3433-80-5 邻溴溴苄 | CAS号40138-16-7 2-甲酰基苯硼酸 | CAS号50777-76-9 2-二苯基膦苯甲醛 | CAS号14944-23-1 3-甲基-3,4-二氢-2H-萘-1-酮 | CAS号226089-17-4 2-dicyclohexylp... | CAS号267668-91-7 Benzaldehyde, 2... | CAS号669091-00-3 2-[二(3,5-二甲基苯基)... | CAS号6630-33-7 2-溴苯甲醛 | CAS号630116-52-8 4-(2-甲苯基)哌啶 | CAS号13203-89-9 3-phenacyl-3H-2... | CAS号1210-05-5 联苯-2,2'-二甲醛

合成工艺路线路线简述

    📜邻溴苯甲醛置于对甲苯磺酸体系中,用 乙二醇,甲苯 用作溶剂,以94%的收率获得2-溴苯甲醛乙烯醛
    参考文献:Esters Of (Triarylphosphoranylidene)Carbamic Acid For Effecting Diuresis
    标题:Esters Of (Triarylphosphoranylidene)Carbamic Acid For Effecting Diuresis
    摘要:这项披露描述了(Triarylphosphoranylidene)Carbamic Acid的新型酯类化合物,这些化合物可作为利尿剂.

    海关参考信息

    专利信息


    专利号:US-8957230-B2
    优先权日:2011-06-30
    标 题 :Synthesis of cleistanthin A and derivatives thereof
    发明人:MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
    权利人:MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
    摘要:The present invention provides a method for preparing Cleistanthin A, a diphyllin glycoside, derivatives thereof and intermediates thereto. In particular the present invention provides in one of the aspect a method for synthesis of compound of formula D a key intermediate of diphyllin, which can be carried out in a shorter duration and at an ordinary temperature.

    专利号:US-9650355-B2
    优先权日:2013-01-31
    标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
    发明人:HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
    权利人:KOREA INST SCI & TECH
    摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

    专利号:US-10111867-B2
    优先权日:2015-02-17
    标题:Process and intermediates for the preparation of perampanel
    发明人:MAROM EHUD; RUBNOV SHAI
    权利人:MAPI PHARMA LTD
    摘要:The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.

    专利号:US-2013012727-A1
    优先权日:2011-06-30
    标题 :Synthesis of cleistanthin a and derivatives thereof

    专利号:RU-2014320-C1
    优先权日:1987-09-15
    标题:Method of synthesis of propenoic acid derivatives and their stereoisomers

    专利号:RU-2024511-C1
    优先权日:1986-04-17
    标 题 :Method of synthesis of e-isomers of acrylic acid derivatives

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Vinyl Azides In Heterocyclic Synthesis. Part 6. Synthesis Of Isoquinolines By Intramolecular Aza-Wittig Reaction
    作者:Deirdre M. B. Hickey,A. Roderick Mackenzie,Christopher J. Moody,Charles W. Rees
    摘要:Azidocinnamates Containing Ortho-Carbonyl Substituents Are Versatile Intermediates For Heterocyclic Synthesis. Isoquinolines (8) And (9) Are Formed Under Mild Neutral Conditions By Intramolecular Aza-Wittig Reactions Of Iminophosphoranes, Readily Derived From Azides (1) And (2), Respectively, With Triethyl Phosphite. The Azafluoranthene (10) Can Also Be Prepared From The Azide (3)Via The Isolable Iminophosphoranes

    合成参考文献


    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 188.
    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 186.
    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 184.
    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 189.
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