CAS: 32385-11-8; Sisomycin

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CAS号53179-09-2 硫酸西索米星 | CAS号66065-86-9 3,2',6'-tri-N-a... | CAS号66567-31-5 1-N-ethyl-3,2',... | CAS号58152-03-7 异帕米星 | CAS号26098-04-4 庆大霉素C1a | CAS号52093-21-7 小诺米星 | CAS号56391-56-1 奈替米星

📜3,2',6'-Tri-N-Acetyl-1-Deamino-1-Oxosisomicin置于乙酸铵,盐酸,Sodium Hydroxide,Sodium Cyanoborohydride体系中,用 甲醇 作为反应溶剂,化学反应 75.0H,反应生成 西索米星
参考文献:半合成氨基糖苷类抗菌剂.第9部分.从1-和3-氧代衍生物合成西索霉素和庆大霉素的新型1-和3-取代以及1-和3-表位取代的衍生物
标题:半合成氨基糖苷类抗菌剂.第9部分.从1-和3-氧代衍生物合成西索霉素和庆大霉素的新型1-和3-取代以及1-和3-表位取代的衍生物
摘要:描述了通过与3,5-二叔丁基-1,2-苯并醌反应而将选择性保护的庆大霉素和西索霉素衍生物转化为1-和3-氧代化合物.通过应用适当的还原技术,这些氧代-氨基糖苷已被转化为新颖的1-和3-Epi-,1-和3-脱氨基-1-和-3-羟基-,1-和3-脱氨基-1-和-. 3-表羟基和1-脱氨基衍生物.所述的研究13的1-C NMR参数外延-和1-脱氨基衍生物已导致新颖的解决方案的构象为这些新的氨基糖苷类的分配.
DOI:10.1039/p19810002168

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-7403826-B2
优先权日:2004-12-01
标题 :Method and system for torque/force control of hydraulic actuators
发明人：AGHILI FARHAD; NAMVAR MEHRZAD
权利人:CANADIAN SPACE AGENCY
摘要:A combined scheme of identification and torque control is provided for rotary hydraulic actuators. The composite controller consists of a dynamic feedback linearizing inner loop cascaded with a robust linear feedback outer loop. The proposed controller allows the actuator to generate desired torque irrespective of the actuator motion. In fact, the controller reduces significantly the impedance of the actuator as seen by its external load, making the system an ideal source of torque suitable for many robotics and automation applications. An identification method to extract the parameters of non-linear model of actuator dynamics and to estimate a bound for modeling uncertainty, used for synthesis of the outer optimal controller, is also presented. Results are illustrated experimentally on a pitch actuator of a Schilling industrial robot.

专利号:US-8147805-B2
优先权日:2005-01-05
标题:Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
发明人：YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND
权利人:YANG DAVID; YU DONGFANG; CHANDA MITHU; AZHDARINIA ALI; OH CHANGSOK; KIM E EDMUND; UNIV T EXAS SYSTEM BOARD OF REGENTS
摘要:Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X 1 —Y—X 2 , wherein Y comprises two or more carbohydrate residues covalently attached to one another, X 1 and X 2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X 1 and X 2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:US-8399502-B2
优先权日:2008-09-17
标 题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-4101556-A
优先权日:1975-11-24
标题 :Total synthesis of 2,5-dideoxystreptamines
发明人：KAVADIAS GERRY; BELLEAU BERNARD R
权利人:BRISTOL MYERS CO
摘要:The dextrorotatory and levorotatory isomers of 1,6-Carbamate-3N-carbethoxy-2,5-dideoxystreptamine (I) have been found to be very valuable intermediates useful in the preparation of totally synthetic aminoglycoside antibiotics. An example of such an aminoglycoside antibiotic is 5-deoxykanamycin A.