CAS: 2831-66-5; 2,4-Dichloro-1,3,5-Triazine

该化合物是一个以三环结构为特征的七环有机化合物,含有3个氮原子和3个碳原子;该化合物一般呈现出无色的黄色表面,并因其在三环上存在两个氯分体而具有回活动性而闻名;二氯-三联苯主要用于各种化学中间体的合成,在生产除草剂和染料方面尤其重要;其再活动使其得以参与核生殖器替代反应,使其成为有机合成中有价值的建筑块;此外,该化合物在有机溶剂中溶解,可提高其在各种化学工艺中的效用;然而,与许多氯化化合物一样,它可能对环境和健康造成危害,需要小心地处理和处置;

结构式图片

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ECHA物质C&L通报

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CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号290-87-9 1,3,5-三嗪 | CAS号108-77-0 氰尿酰氯 | CAS号506-77-4 氯化氰 | CAS号71-33-0 5-氮杂尿嘧啶 | CAS号60-29-7 乙醚 | CAS号7647-01-0 盐酸 | CAS号56-23-5 四氯化碳 | CAS号7782-50-5 氯气 | CAS号7709-13-9 4-氯-1,3,5-三嗪-2-胺

合成工艺路线路线简述

  • 合成目标产物 2,4-Dichloro-1,3,5-Triazine 主要起始原料 1,3,5-Triazine
  • (文献来源)合成步骤主要原料 1,3,5-Triazine
三聚氯氰置于lithium Aluminium Tetrahydride,乙醚体系中,化学反应生成2,4-二氯-1,3,5-三嗪
参考文献:Triazines. Vii. The Reaction Of Cyanuric Chloride With Lithium Aluminum Hydride1
标题:Triazines. Vii. The Reaction Of Cyanuric Chloride With Lithium Aluminum Hydride1
摘要:
Doi:10.1021/ja01636A065

专利信息


专利号:EP-1575929-B1
优先权日:2002-12-19
标 题 :The method for production of semi-finished products useful in synthesis of paclitaxel
发明人:KOLESINSKA BEATA; KAMINSKI J ZBIGNIEW; KAMINSKA E JANINA
权利人:AGROPHARM S A
摘要:The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.

专利号:WO-8103020-A1
优先权日:1980-04-22
标 题 :Triazine synthesis
发明人:HARRIS R
权利人:COMMW SCIENT IND RES ORG; HARRIS R
摘要:A process for the synthesis of substituted 1,3,5-triazine compounds of the general formula: (FORMULA) wherein Rs and Rs, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamino, arylamino, alkyl-arylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that Rs and Rs are not both halogen); and Rs is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryl; comprises reaction of a substituted halomethyleneiminium salt with a substituted N-cyanoamidine, N-cyanoguanidine, N-cyanocarbamimidate or N-cyanocarbamidothioate. Substituted 1,3,5-triazine compounds having fungal germination inhibition properties are also disclosed. The following compounds 1) 2-chloro-4-phenyl-1,3,5-triazine, 2) 2-chloro-4-phenoxymethyl-6-phenyl-1,3,5-triazine, 3) 2-N-methylphenylamino-4-phenyl-1,3,5-triazin, 4) 2-chloro-4-cyanomethyl-6-phenyl-1,3,5-triazine are also disclosed and claimed.

专利号:US-7417139-B2
优先权日:2003-08-30
标 题 :Method for polynucleotide synthesis
发明人:DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H; DELLINGER GERALDINE F
权利人:AGILENT TECHNOLOGIES INC
摘要:Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively R1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R2 or R3 is a hydroxyl protecting group; and the other of R2 or R3 is a reactive group capable of reacting with the reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is the exocyclic amine triaryl methyl protecting group.

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人:KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-2006040283-A1
优先权日:2001-04-11
标题:Methods of manipulating nucleic acids
发明人:XIANG CHARLIE; BROWNSTEIN MICHAEL J
权利人:US GOV HEALTH & HUMAN SERV
摘要:Methods are provided for labeling nucleic acid molecules for use in hybridization reactions, and kits employing these methods. The level of labeling is increased by including one or more reactive modifications, such as amine-modifications, into the primers used to initiate synthesis of the nucleic acid molecule, for instance through random-primed reverse transcription. Also provided are modified random primers (such as amine-modified random primers) useful in these methods, labeling and hybridization kits comprising such primers, labeled nucleic acid molecules and mixtures of molecules, and methods for using them. Methods are also provided for amplifying a nucleic acid template contained within extremely small samples, in some cases as little as one cell. In particular embodiments, a single random primer is used for all steps of the amplification method. The nucleic acid template can either be of cellular or viral origin. The disclosure also provides an improved method of fixing cells, tissue sections, or laser microdissected sections from which RNA can be obtained for subsequent use as RNA templates or for generating labeled probe.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
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