CAS: 2752-65-0; (Z)-4-((1S,3Ar,5S,11R,14As)-8-Hydroxy-2,2,11-Trimethyl-13-(3-Methylbut-2-En-1-yl)-11-(4-Methylpent-3-En-1-yl)-4,7-Dioxo-1,2,5,7-Tetrahydro-11H-1,5-Methanofuro[3,2-G]Pyrano[3,2-B]Xanthen-3A(4H)-yl)-2-Methylbut-2-Enoic Acid

📜Pyridinium Gambogate置于盐酸体系中,用 乙醚,水 用作溶剂,化学反应 1.0H,以99%的收率获得藤黄酸
参考文献:笼状藤黄素,一种具有强大抗疟疾活性的新型化学支架.
标题:笼状藤黄素,一种具有强大抗疟疾活性的新型化学支架.
摘要:笼状藤黄原体(cgxs)构成了由藤黄属热带/亚热带树木生产的天然产物家族,具有独特的化学结构,其定义为在an吨酮部分的c环上存在笼状支架,并表现出广泛的生物活动.在这里,我们显示合成的cgxs在红细胞内阶段对人疟疾的致病性寄生虫-恶性疟原虫表现出抗疟疾活性.通过在笼状黄酮的a环上连接一个三苯基phosph基团,可以大大提高它们的活性.具体而言,发现cr135和cr142是高效的抗疟疾抑制剂,有效浓度为50%,低至约10 Nm.Cgxs在多个红细胞内阶段影响疟原虫,成熟的阶段(滋养体和裂殖体)比不成熟的环更易受伤害.在cgx治疗后数小时内,疟原虫显示出明显的形态变化,寄生虫病(感染的红细胞百分比)显着降低以及线粒体异常分裂.但是,Cgx并不靶向线粒体电子传输链,也不是靶向药物atovaquone的靶标和一些临床前候选药物.Cgx在低微摩尔水平下对人hek293细胞具有细胞毒性,这导致前导化合
Doi:10.1128/aac.01220-16

专利信息

专利号:WO-2025120678-A1
优先权日:2023-12-08
标 题 :A process for synthesis of poly-γ-glutamic acid
发明人：DHARNE MAHESH SHANTAPPA; YADAV RAKESHKUMAR JAYNARAYAN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a field of biopolymers and microbial fermentation. Specifically, the present invention relates to a microbial process for industrial production of a biopolymer. More particularly, the present invention relates to a process for synthesis of poly-γ-glutamic acid from maltose and sugarcane bagasse. The process of the present invention is devoid of pre- treating of raw materials (biomass) thereby eliminating environmental and cost concerns.

专利号:US-2023212621-A1
优先权日:2020-06-09
标题:Process for synthesis of poly-gamma-glutamic acid
发明人：DHARNE MAHESH SHANTAPPA; NAIR PRANAV GIRIJAVALLABHAN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention overcomes the problem of processes yielding poor quantities of poly-gamma-glutamic-acid (γ-PGA) by providing a process and a novel medium for synthesis of γ-PGA in the presence of Bacillus paralicheniformis MCC 196. Wherein, the novel medium comprises tomato waste alone for cost effective and greener production of γ-PGA with yield of 40 g/L. In another process, non-sterile fermentation employs the use of a medium high in sugar content. Wherein, sucrose is used in concentrations up to 50% to obtain more than 280 g/L of poly gamma glutamic acid. The disclosed process is scalable and provides immense economic advantages.

专利号:US-2025304985-A1
优先权日:2022-04-08
标题 :Genetically Engineered Plants for Increased Production of Vindoline
发明人：LEE-PARSONS CAROLYN; COLE LAUREN F
权利人:UNIV NORTHEASTERN
摘要:Two novel transcription factors, CrDELLA1 and CrDELLA2, are described in Catharanthus roseus plants. The DELLA transcription factors have a regulatory role in the synthesis of vinblastine and vincristine, two important anti-cancer compounds that have proved difficult to obtain in sufficient quantities. The present technology provides genetically modified C. roseus plants having enhanced DELLA activity, which leads to activation of multiple enzymes in the biosynthetic pathway leading to vinblastine and vincristine. The genetic modifications can be used together with activation of plant defense mechanisms and responses to light in order to boost vinblastine and vincristine synthesis.

专利号:US-11492445-B2
优先权日:2017-08-30
标 题:Direct synthesis of glycidyl azide polymers
发明人：FENG XIAOSHUANG; BOOPATHI Senthil; HADJICHRISTIDIS NIKOLAOS; GNANOU YVES
权利人:UNIV KING ABDULLAH SCI & TECH
摘要:Embodiments of the present disclosure describe a method of synthesizing a glycidyl azide homopolymer comprising contacting a glycidyl azide monomer, an initiator, and a Lewis acid sufficient to form the glycidyl azide homopolymer; wherein the glycidyl azide homopolymer is directly polymerized from the glycidyl azide monomer. Embodiments of the present disclosure further describe a method of making a glycidyl azide polymer comprising contacting one or more of a glycidyl azide monomer, an epoxide monomer, carbon dioxide, an initiator, and a Lewis acid in a reaction medium to form a glycidyl azide polymer.

专利号:US-12416029-B2
优先权日:2016-06-27
标 题 :Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
发明人：FACCHINI PETER JAMES; CHEN XUE; COLBECK JEFFREY C; TUCKER JOSEPH E
权利人:ANTHEIA INC
摘要:Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAsâ€?) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.

专利号:US-2025075200-A1
优先权日:2022-05-27
标题:Biocatalysts for organic synthesis
发明人：ALVARENGA DA SILVA NATALIA; STRIDFELDT ELIN; VOLKOV ALEXEY; RUGGIERI FEDERICA; HENDIL-FORSSELL PETER; RÄMGÃ…RD CARL; BAUMGARTEN THOMAS; MATTEY ASHLEY; MURPHY VINCE; THOMPSON MATTHEW P; CLEMMENTS ALDEN M; GERGEL SEBASTIAN
权利人:ENGINZYME AB
摘要:The invention relates to a biocatalyst for organic synthesis, comprising a controlled porosity silica (CPS) as support material, wherein the pore diameter is between about 20 and about 100 nm, said support material comprising an amino-functionalized surface; and one or more catalytically active enzyme(s) immobilized on the support material. The invention also relates to uses of such biocatalysts and methods of manufacture thereof.