CAS: 262429-49-2; (R)-3-Amino-3-(3-Chlorophenyl)Propanoic Acid

上下游产品

CAS号262429-48-1 (+/-)-N-Phenyla... | CAS号2039-85-2 3-氯苯乙烯 | CAS号68208-21-9 3-氨基-3-(3-氯苯基)丙酸 | CAS号587-04-2 3-氯苯甲醛 | CAS号1866-38-2 间氯肉桂酸

3-氯苯乙烯置于cal-B (Lipase B From Candida Antarctica),水体系中,用 异丙醇,甲苯 用作溶剂,化学反应 19.0H,反应生成(R)-3-氨基-3-(3-氯苯基)-丙酸
参考文献:通过脂酶催化β-内酰胺的对映选择性环裂解制备对映体纯的β-芳基取代的β-氨基酸和4-芳基取代的β-内酰胺的新途径
标题:通过脂酶催化β-内酰胺的对映选择性环裂解制备对映体纯的β-芳基取代的β-氨基酸和4-芳基取代的β-内酰胺的新途径
摘要:开发了一种简单有效的直接酶法,用于通过cal-B(南极假丝酵母的脂肪酶b )催化的对映选择性(e > 200)环合成4-芳基取代的β-内酰胺和相应的β-氨基酸对映体1当量裂解相应的外消旋β-内酰胺.60oc下i-Pr 2 O中的h 2 O含量.可以容易地分离出产物(R)-β-氨基酸(ee>=98%,产率>=42%)和未反应的(S)-β-内酰胺(ee>=95%,产率>=41%).对映体β-内酰胺与18%hcl的开环得到相应的对映体纯β-氨基酸盐酸盐(ee>=99%).
Doi:10.1002/adsc.200505434

专利信息

专利号:US-9663516-B2
优先权日:2014-12-18
标题:Bicyclic-pyrimidinedione compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; GRILLO MARK; KANE BRIAN; MCDOWELL ROBERT; SONG YONGHONG; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.