CAS: 2489-77-2; 1,1,3-Trimethylthiourea

该化合物是一种硫尿素衍生物,其特点是含有硫的功能组和甲基替代物,该化合物主要用作有机合成的试剂,特别是用于制造异环化合物,以及作为各种化学反应的催化剂或中间体,其结构稳定性和活性使其适合于医药,农用化学品和材料科学的应用,硫尿素的出现增强了其参与氢联结和协调化学的能力,为选择性合成和分子识别提供了优势,甲基混合物有助于提高有机溶剂的溶解性,促进其在各种反应条件下的使用.

英文名称1,1,3-Trimethylthiourea
中文名称1,1,3-三甲基硫脲
IUPAC名称1,1,3-trimethylthiourea
其它别名三甲基硫脲; Trimethylthiourea
CAS编号2489-77-2
MFCD编号:MFCD00059148
EINECS号:219-644-0
FDA UNII编号:5MHD6IL0A4
分子式:C4H10N2S
分子量:118.21
产品CID: 1201360
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
产品信息参考;;
InChIKey: JAEZSIYNWDWMMN-UHFFFAOYSA-N
InChI=1S/C4H10N2S/c1-5-4(7)6(2)3/h1-3H3,(H,5,7)…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

2782-91-4 6972-05-0 534-13-4

物理性质

熔点84 °C
沸点221.2 °C at 760 mmHg
闪点33.8 °C
密度1.022g/cm3
pKa:15.29±0.70(预测)
PSA:15.27
LogP:0.0523
折射率1.52
蒸汽压8.9mmHg at 25°C
溶解性0.1 to 1.0 mg/mL at 68° F (NTP, 1992)
敏感性An organosulfide amide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
外观形态白色至几乎白色固体
储存条件室温
产品应用该化合物用于合成许多化合物.

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇体系中,化学反应生成三甲基硫脲
参考文献:Kohlrausch; Wagner,Zeitschrift Fur Physikalische Chemie,Abteilung B: Chemie Der Elementarprozesse,Aufbau Der Materie,1940,Vol. 45,P. 231,235
标题:Kohlrausch; Wagner,Zeitschrift Fur Physikalische Chemie,Abteilung B: Chemie Der Elementarprozesse,Aufbau Der Materie,1940,Vol. 45,P. 231,235

海关参考信息

2921199090-其他无环单胺
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专利信息

专利号:US-9809565-B2
优先权日:2013-07-05
标题 :Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas
发明人：LETINOIS ULLA; NETSCHER THOMAS; ACKERMANN STEPHAN
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.

专利号:US-2010221809-A1
优先权日:2008-12-23
标题:Compositions and Methods for the Isolation of Biologically Active Proteins
发明人：FORMAN HENRY J; MEYER MATTHEW P
权利人:UNIV CALIFORNIA
摘要:This invention is directed to compositions and methods for the isolation and further characterization of eukaryotic, mammalian, and/or human PC-PLC. In addition, the present invention discloses methods for the synthesis of an affinity chromatography resin for the isolation and purification of biologically active proteins, including eukaryotic PC-PLC.