CAS: 24202-74-2; 4-(Methoxycarbonyl)Nicotinic Acid

该化合物是其丙烯环结构的有机化合物,其特征是含有一个氮原子的六人芳香环,该化合物有两种功能组:甲氧碳基集团(-COOCH3)和有助于其酸性和再活性的碳酸集团(-COOH),这些组的存在使它成为有机合成的多种中间体,特别是在制药和农用化学品方面.甲基碳基集团增强了该化合物在有机溶剂中的溶性,而碳基酸集团可以参与各种化学反应,例如化和恐吓.此外,该化合物的丙烯酸集团可以与金属离子(-COH3)和碳酸集团(-COOH)协调,使其在协调化学方面有用.

结构式图片

相似化合物

38070-80-3 1678-52-0 1796-83-4

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

methanol cinchomeronic anhydride pyridine-3,4-dicarboxylic acid 3-methyl ester ethanol dimethyl 3,4-pyridinedicarboxylate pyridin-3-carboxylic acid-4-carboxamide 3,4-pyridinecarboxylic acid 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone

合成工艺路线路线简述

    📜3,4-吡啶二羧酸置于乙酸酐体系中,用 二氯甲烷 用作溶剂,化学反应 19.0H,反应生成3-羧酸-4-羧酸甲酯吡啶
    参考文献:Synthesis Of 11-Amino-Substituted-9-Methoxy-5-Methyl-6H-Pyrido[4,3-B]-Carbazoles
    标题:Synthesis Of 11-Amino-Substituted-9-Methoxy-5-Methyl-6H-Pyrido[4,3-B]-Carbazoles
    摘要:A Route To 11-Amino-Substituted-6H-Pyrido[4,3-B]Carbazoles Has Been Studied. Thus,Condensation Of 2-(4-Lithiopyridine-3-yl)-4,4-Dimethyloxazoline With 2-Acetyl-5-Methoxy-1-Phenylsulphonylindole Led To A Low Yield Of The Expected Alcohol,Which Upon Hydrolysis Gave A Complex Mixture. A Better Starting Building Block Was 4-Acetyl-N,N-Diisopropylnicotinamide Obtained Either From N,N-Diisopropyl-4-Lithionicotinamide (Low Yield) Or From Pyridine-3,4-Dicarboxylic Anhydride,Using A 4-Step Sequence. This Compound Was Treated With 2-Lithio-5-Methoxy-1-Phenylsulphonylindole,Affording N,N-Diisopropyl-4-[1-(5-Methoxy-1-Phenylsulphonylindol-2-yl)-1-Hydroxyethyl]Nicotinamide. Hydrolysis And Then Reduction Led To 4-[1-(5-Methoxy-1-Phenylsulphonylindol-2-yl)-Ethyl]Nicotinic Acid Whose Amides Were Cyclized By Phosphorus Trichlorideoxide. Finally,The Title Compounds Were Obtained By Raney-Nickel Reduction-Elimination Of The 6-Phenylsulphonyl Protecting Group.
    Doi:10.1039/p19910003165

    海关参考信息

    专利信息


    专利号:US-5098462-A
    优先权日:1985-08-20
    标 题 :Substituted semi-carbazones and related compounds
    发明人：ANDERSON RICHARD J; LEIPPE MICHAEL M; BAMBERG JOE T
    权利人:SANDOZ LTD
    摘要:Substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

    专利号:US-5098466-A
    优先权日:1985-08-20
    标 题 :Compounds
    发明人：ANDERSON RICHARD J; LEIPPE MICHAEL M; BAMBERG JOE T
    权利人:SANDOZ LTD
    摘要:Substituted semicarbazones, thiosemicarbazones and isothiosemicarbazones and salts thereof, intermediates therefor, synthesis thereof, and the use of said compounds for the control of weeds.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Lou, S.; Zhang, J., Science of Synthesis: Knowledge Updates, (2012) 2, 276.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知