专利号:US-4410710-A 优先权日:1981-09-25 标题 :Conversion of iridoids to prostaglandins 发明人:BERKOWITZ WILLIAM F; CHOUDHRY SATISH C; HRABIE JOSEPH A 权利人:UNIV CITY 摘要:Naturally occurring iridoids provide the starting material for a unique synthesis sequence to produce prostaglandin intermediates. The iridoid lactone is hydrogenated, converted to an acetal, and rings opened to introduce the carbonyl octenyl side chain in six steps. The intermediate can be converted to prostaglandin as previously demonstrated.
参考文献:10.5281/zenodo.5794106 摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106 参考文献:10.1248/cpb.50.1395 摘要:Takeda Y, Shimidzu H, Mizuno K, Inouchi S, Masuda T, Hirata E, Shinzato T, Aramoto M, Otsuka H. An iridoid glucoside dimer and a non-glycosidic iridoid from the leaves of Lasianthus wallichii. Chem Pharm Bull (Tokyo). 2002 Oct;50(10):1395–7. doi: 10.1248/cpb.50.1395. 参考文献:10.1248/cpb.52.1356 摘要:Kim YL, Chin YW, Kim J, Park JH. Two new acylated iridoid glucosides from the aerial parts of Paederia scandens. Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1356–7. doi: 10.1248/cpb.52.1356.