CAS: 2049-80-1; Diethyl Allylmalonate

相似化合物

3195-24-2 133-13-1 17920-23-9

上下游产品

allyl iodid sodium diethylmalonate ethanol allylmalonic acidallyl-(1-methyl-butyl)-malonic acid diethyl ester 3-chloro-5-chloromethyl-dihydro-furan-2-one 4-Pentenenitrile ethyl 4-oxobutanoate

Triethyl Pent-4-Ene-1,2,2-Tricarboxylate置于sodium Ethanolate体系中,用 四氢呋喃 用作溶剂,化学反应 1.0H,以87%的收率获得烯丙基丙二酸二乙酯
参考文献:铁催化,氢介导的 1,6-烯炔和二炔还原环化:双(亚氨基)吡啶配体参与的证据
标题:铁催化,氢介导的 1,6-烯炔和二炔还原环化:双(亚氨基)吡啶配体参与的证据
摘要:双(亚氨基)吡啶铁二氮配合物(((i)pr)pdi)fe(n(2))(2)催化氢介导的烯炔和二炔的还原环化,其周转频率与已建立的贵金属催化剂相当. 氨基,含氧和碳基底物很容易环化为相应的杂环和碳环,在 23 摄氏度时含有 5 Mol % 铁和 4 Atm H(2).选定的底物与 N(2) 下的铁化合物之间的化学计量反应) 气氛建立了从异丙基芳基取代基到烯炔或二炔底物的转移脱氢.通过 (1) H NMR 光谱结合氘标记实验对催化反应进行原位监测,建立了快速环化,然后是限制营业额的氢化.
Doi:10.1021/ja902478P

专利信息

专利号:US-6753449-B2
优先权日:2001-10-09
标题 :Cleavable linker for solid phase synthesis
发明人：GUO MAOJUN
权利人:ARQULE INC
摘要:Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.

专利号:EP-2630116-B1
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:US-2013281580-A1
优先权日:2010-10-20
标题:Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent

专利号:US-8461107-B2
优先权日:2008-04-28
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.