CAS: 19427-28-2; (S)-2-Formamidosuccinic Acid

相似化合物

1152-61-0 119062-05-4 136083-57-3

上下游产品

CAS号56-84-8 L-天门冬氨酸 | CAS号77287-34-4 甲亚胺酸 | CAS号107-31-3 甲酸甲酯 | CAS号64-18-6 甲酸 | CAS号2258-42-6 甲乙酐 | CAS号103-70-8 甲酰苯胺 | CAS号34433-90-4 3-甲酰胺丙酸甲酯 | CAS号33605-76-4 N-甲酰基-L-天冬氨酰-L-... | CAS号2311-21-9 甲酰基-L-苯丙氨酸甲酯

📜L-天门冬氨酸 以 Formamide 用作溶剂,化学反应生成N-甲酰-L-天冬氨酸
参考文献:N-Formylation Of Amino Carboxylic Compounds With Formamide
标题:N-Formylation Of Amino Carboxylic Compounds With Formamide
摘要:氨基羧酸的氨基氮原子通过将氨基羧酸与甲酰胺反应而被甲酰化.

专利信息

专利号:WO-0037486-A1
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO; QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-α- and β-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-6617127-B2
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER J L M; SONKE THEODORUS; WAGNER ADOLF F V
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-alpha-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-alpha- and beta-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:EP-1140982-B1
优先权日:1998-12-22
标 题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl- alpha -L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl- alpha - and beta -L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-4789758-A
优先权日:1985-01-07
标题 :Process for the production of an N-protected-L-α-aspartyl-L-phenylalanine
发明人：TAKEMOTO TADASHI; YUKAWA TOSHIHIDE; HISAMITSU KUNIO
权利人:AJINOMOTO KK
摘要:A process is described for the synthesis of N-protected-L-α-aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R 1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and L-phenylalanine in an aqueous medium in the presence of R 2 , where R 1 may be an alkali metal salt, alkaline earth metal salt, ammonium salt or organic amine salt, and R 2 may be an ammonium salt or an alkali or alkaline earth metal salt of an inorganic or organic acid.

专利号:US-4526985-A
优先权日:1982-08-06
标 题:Process for the preparation of the anhydride of N-formyl-L-aspartic acid
发明人：GIOBBIO VINCENZO; ORNATO GIORGIO; BURACCHI LIVIO; MANGIA ALBERTO
权利人:PIERREL SPA
摘要:A process for the preparation of the anhydride of N-formyl-L-aspartic acid by reacting L-aspartic acid with nearly stoichiometric amounts of formic acid and acetic anhydride, under controlled conditions of temperature, reaction and addition times. The product is a known intermediate in the synthesis of α-L-aspartyl-L-phenylalanine methyl ester, a known sweetening agent.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.