CAS: 18368-57-5; 6-Methylpyridine-2-Thiol

上下游产品

CAS号5315-25-3 2-溴-6-甲基吡啶

2-甲基-6-氯吡啶置于sodium Hydrogen Sulfide体系中,用 1,2-丙二醇 用作溶剂,化学反应 2.0H,以49%的收率获得2-巯基-6-甲基吡啶
参考文献:Naclo2介导的吡啶-2-磺酰氯的制备及手性磺酰胺的合成
标题:Naclo2介导的吡啶-2-磺酰氯的制备及手性磺酰胺的合成
摘要:开发了一种以水用作溶剂,通过 Naclo2 介导的氮杂芳烃硫醇氧化氯化制备氮杂芳烃磺酰氯的简单方法.通过简单的提取和浓缩,容易纯化得到高产率的产品.氮杂芳烃磺酰氯易于与手性胺缩合得到手性磺酰胺.图形概要
Doi:10.1080/17415993.2020.1775834

专利信息

专利号:US-8344118-B2
优先权日:2007-10-31
标 题 :Preparation and isolation of 5′ capped MRNA
发明人：KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
权利人:APPLIED BIOSYSTEMS LLC; KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
摘要:The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

专利号:US-9828386-B2
优先权日:2013-11-15
标题:Sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof
发明人：TANG YAJIE; LI JIANLONG; ZHAO WEI; LI HONGMEI
权利人:UNIV HUBEI TECHNOLOGY
摘要:The present invention discloses a sulfur-substituted podophyllotoxin derivative, synthesis method thereof, and use thereof. The present invention introduces a rigid aromatic heterocyclic compound, as well as a further sulfonamidated product of 3-amino-5-mercapto-1,2,4-triazole, 2-amino-5-mercapto-1,3,4-thiadiazole, 4-methylbenzenesulfonyl chloride, or 4-methoxybenzenesulfonyl chloride as a substituent group, into position 4 of the C-ring of podophyllotoxin or 4′-demethylepipodophyllotoxin to obtain the podophyllotoxin derivative shown in formula (V), said derivative having significantly increased antitumor activity and reduced toxic side effects. Experiments on in vitro tumor cell inhibition indicate that the antitumor activity of the compound of formula (V) of the present invention is significantly higher than the antitumor activity of podophyllotoxin or 4′-demethylepipodophyllotoxin.

专利号:CN-111699248-A
优先权日:2018-01-31
标题:Biocatalysts and methods for the synthesis of mixed disulfide conjugates of thienopyridine compounds

专利号:US-12188069-B2
优先权日:2018-01-31
标 题 :Biocatalyst and methods for synthesizing mixed disulfide conjugates of thienopyridine compounds
发明人：ZHANG HAOMING
权利人:UNIV MICHIGAN REGENTS
摘要:The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.