专利号:US-3796697-A 优先权日:1971-11-02 标 题:Pentapeptide 发明人:FLOURET G 权利人:ABBOTT LAB 摘要:THE SYNTHESIS OF THE PENTAPEPTIDE GLY-LEU-ARG-PRO-GLY-AMIDE CARRYING EASILY REMOVABLE PROTECTIVE GROUPS ON THE NA OF GLYCINE AND ON THE ARG MOIETY IS DESCRIBED; THE CORRESPONDNGLY PROTECTED TERAPEPTIDE IS USED AS THE STARTING MATERIAL. THE NEW PENTAPEPTIDE, UPON REMOVAL OF THE PROTECTIVE GROUP ON THE AMINO GROUP OF THE GLYCINE MOIETY IS AN IMPORTANT INTERMEDIATE FOR THE PREPARATION OF THE GONADOTROPIN-RELEASING HORMONE.
专利号:US-5998580-A 优先权日:1995-10-13 标 题:Photosensitive caged macromolecules 发明人:FAY FREDERICK F; CARRAWAY ROBERT; IKEBE MITSUO; WALKER JEFFREY 摘要:Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including a photolabile molecule; and (b) incorporating the amino acid into a peptide during synthesis, wherein incorporation of the amino acid into the peptide produces a photosensitive peptide. Also disclosed is a method of introducing a photosensitive cleavage site into a synthetic peptide, including synthesizing a synthetic peptide having at least one photolabile amino acid, wherein the photolabile amino acid is positioned within the synthetic peptide so that upon irradiation the synthetic peptide is cleaved.
参考文献:10.1007/7081_2019_35 摘要:Josse S, Postel D. Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars. 2019. In: Topics in Heterocyclic Chemistry.