CAS: 1605-65-8; Bis(Dimethylamido)Phosphoric Chloride

该化合物是一种化学化合物,其特点是磷酰胺结构,它是在极地有机溶剂中可溶解的无色黄色液体,因其在各种化学应用中用作有机合成中的试剂和含有磷的化合物而闻名,它具有磷酰氨衍生物的典型特性,包括在化学反应中作为磷源的能力,氯化物组的存在有助于其反应,使其在其他含有磷化合物的合成中有用.此外,必须谨慎处理该物质,因为它在接触时可能对健康造成危害,包括潜在毒性.在实验室环境中与该化合物合作时,应当观察适当的安全措施.总体而言,N,N,NO,N欧元,N-欧元,硝基甲基磷磷二氮氯化物是合成化学领域的多种试剂.

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物理性质

MSDS等安全信息

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号3348-44-5 双(二甲基氨)氯膦 | CAS号124-40-3 二甲胺 | CAS号680-31-9 六甲磷酰三胺(HMPA) | CAS号102269-11-4 N,N-dibenzyl-O-... | CAS号677-43-0 N,N-二甲基磷氨基二氯化物 | CAS号15743-13-2 4-Cyclopentene-... | CAS号22949-94-6 2-(dichlorophos... | CAS号64991-65-7 ((chlor°Carbony... | CAS号143520-19-8 2,3,4,6-四-O-苄基-... | CAS号143520-27-8 | CAS号1440-97-7 Bis(N,N-dimethy... | CAS号680-31-9 六甲磷酰三胺(HMPA) | CAS号115-26-4 双(二甲胺基)磷酰氟 | CAS号354-43-8 Dimethylamidoph... | CAS号2346-29-4 4-Oxa-2-aza-3-p... | CAS号2404-65-1 N-[dimethylamin... | CAS号677-43-0 N,N-二甲基磷氨基二氯化物

合成工艺路线路线简述

    📜双(二甲基氨)氯膦置于臭氧体系中,用 二氯甲烷 用作溶剂,以95%的收率获得双(二甲胺基)氯酸磷
    参考文献:Caminade,Anne-Marie; El Khatib,Fayez; Baceiredo,Antoine,Phosphorus And Sulfur And The Related Elements,1987,Vol. 29,P. 365-368
    标题:Caminade,Anne-Marie; El Khatib,Fayez; Baceiredo,Antoine,Phosphorus And Sulfur And The Related Elements,1987,Vol. 29,P. 365-368

    海关参考信息

    专利信息


    专利号:US-9650355-B2
    优先权日:2013-01-31
    标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
    发明人：HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
    权利人:KOREA INST SCI & TECH
    摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

    专利号:US-2002107391-A1
    优先权日:2000-10-25
    标 题:Process for the synthesis of an endothelin receptor antagonist
    发明人：FREY LISA F; CHEN CHENG Y; LI JING; SONG ZHIGUO J; TAN LUSHI; TILLYER RICHARD D; TSCHAEN DAVID M; ZHAO MATTHEW M
    摘要:The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:

    专利号:US-7825149-B2
    优先权日:2006-01-19
    标 题 :Substituted imidazoles
    发明人：CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
    权利人:PFIZER LTD
    摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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    主要参考文献

    [参考文献]: Adriaan J. Minnaard, Et Al. Total Synthesis Of Neohedycaryol. Its Possible Role In The Biosynthesis Of Eudesmane Sesquiterpenes. J Org Chem. 1997 Apr 18;62(8):2344-2349.
    [参考文献]: Vladimir N. Zhabinskii, Et Al. Relative And Absolute Configuration Of Allohedycaryol. Enantiospecific Total Synthesis Of Its Enantiomer. J Org Chem. 1996 Jun 14;61(12):4022-4027.

    合成参考文献


    摘要:Wicha, J., Science of Synthesis, (2009) 48, 187.
    摘要:Wicha, J., Science of Synthesis, (2009) 48, 187.
    摘要:Schramm, M. P., Science of Synthesis, (2009) 46, 514.
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