CAS: 149231-65-2; 3-[2-[[2-[[2-Acetamido-3-(4-Hydroxyphenyl)Propanoyl]Amino]-3-Methylbutanoyl]Amino]Propanoylamino]-4-[(4-Methyl-2-Oxochromen-7-yl)Amino]-4-Oxobutanoic Acid

上下游产品

CAS号26093-31-2 7-氨基-4-甲基香豆素 | CAS号112883-29-1 FM°C-D-酪氨酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号144120-53-6 N-(9-芴甲氧羰基)-L-天... | CAS号26093-31-2 7-氨基-4-甲基香豆素

📜Ac-Tyr(Obzl)-Val-Ala-Asp(Obzl)-Mca置于palladium On Activated Charcoal 氢气体系中,用 甲醇 用作溶剂,以89.3%的收率获得n-乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨酸-7-氨基-4-甲基香豆素
参考文献:氨基酸和多肽.加大码 使用新开发的乙酰化试剂合成ac-Tyr-Val-Ala-Asp-Mca.
标题:氨基酸和多肽.加大码 使用新开发的乙酰化试剂合成ac-Tyr-Val-Ala-Asp-Mca.
摘要:通过对h-Phe-Leu-Ch2Cl进行环化,然后用乙酸酐进行乙酰化,制得2-乙酰氧基-3-苄基-5-甲基-6-异丁基吡嗪.该吡嗪衍生物可以与氨基酸或肽的氨基反应以产生乙酰基氨基酸或乙酰基肽,而不会使tyr,Ser和thr的羟基乙酰化.使用该乙酰化试剂,制备了白介素i(il-1)加工酶的特异性底物ac-Tyr-Val-Ala-Asp-Mca.
Doi:10.1248/cpb.43.1336

专利信息

专利号:US-8329686-B2
优先权日:2006-08-29
标题:Isatin analogues and uses therefor
发明人：MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN
权利人:MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN; UNIV WASHINGTON
摘要:Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).