CAS: 1440209-96-0; N1-Hydroxy-N3-Phenethylisophthalamide
- 英文名称N1-Hydroxy-N3-Phenethylisophthalamide
- 中文名称N1-羟基-N3-(2-苯基乙基)-1,3-苯二甲酰胺
- IUPAC名称N1-hydroxy-N3-phenethylisophthalamide
- 其它别名N1-Hydroxy-N3-(2-Phenylethyl)-1,3-Benzenedicarboxamide ; N1-Hydroxy-N3-Phenethylisophthalamide ; N-Hydroxy-N′-Phenethyl-Isophthalamide
- CAS编号1440209-96-0
- MFCD编号:MFCD26383435
- 分子式:C16H16N2O3分子量:284.32
- 产品CID: 669748
- 产品分类生物化工 → 抑制剂 → 表观遗传学(Epigenetics)
物理性质
MSDS等安全信息
上下游产品
benzene 1,3-dicarboxylic acid monomethyl ester phenethylamine 17H17NO3C17H17NO3合成工艺路线路线简述
📜Methyl 3-[(2-Phenylethyl)Carbamoyl]Benzoate置于羟胺,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,水 用作溶剂,化学反应生成N1-羟基-N3-(2-苯基乙基)-1,3-苯二甲酰胺
参考文献:Discovery Of The First Histone Deacetylase 6/8 Dual Inhibitors
标题:Discovery Of The First Histone Deacetylase 6/8 Dual Inhibitors
摘要:We Disclose The First Small Molecule Histone Deacetylase (Hdac) Inhibitor (3,Brd73954) Capable Of Potently And Selectively Inhibiting Both Hdac6 And Hdac8 Despite The Fact That These Isoforms Belong To Distinct Phylogenetic Classes Within The Hdac Family Of Enzymes. Our Data Demonstrate That Meta Substituents Of Phenyl Hydroxamic Acids Are Readily Accommodated Upon Binding To Hdac6 And,Furthermore,Are Necessary For The Potent Inhibition Of Hdac8.
Doi:10.1021/jm400390R
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912210000-苯甲醛
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, Weïwer M, Zhang YL, Holson EB. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. doi: 10.1021/jm400390r. Epub 2013 May 29.
合成参考文献
合成方法参考DOI号:10.1021/jm400390r
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