CAS: 1365888-06-7; (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylic Acid

上下游产品

Ethyl (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylate 1365889-11-7
(E)-Ethyl 3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1-(Tetrahydro-2H-Pyran-2-yl)-1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylate 1365889-10-6
(E)-4-(2-(2-Chloro-4-Fluorophenyl)-1-(1-(Tetrahydro-2H-Pyran-2-yl)-1H-Indazol-5-yl)But-1-En-1-yl)Benzaldehyde 1365889-09-3

📜Dicyclohexylammonium (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1-(Tetrahydro-2H-Pyran-2-yl)-1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylate置于硫酸体系中,用 水,甲苯 用作溶剂,化学反应生成(E)-3-[4-[(E)-2-(2-氯-4-氟苯基)-1-(1H-吲唑-5-基)丁-1-烯-1-基]苯基]-2-丙烯酸
参考文献: Process For The Preparation Of (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylic Acid[fr] Procédé Pour La Préparation D'Acide (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophényl)-1-(1H-Indazol-5-yl)But-1-én-1-yl)Phényl)Acrylique
标题: Process For The Preparation Of (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophenyl)-1-(1H-Indazol-5-yl)But-1-En-1-yl)Phenyl)Acrylic Acid[fr] Procédé Pour La Préparation D'Acide (E)-3-(4-((E)-2-(2-Chloro-4-Fluorophényl)-1-(1H-Indazol-5-yl)But-1-én-1-yl)Phényl)Acrylique
摘要:描述了一种用于制备雌激素受体调节化合物(E)-3-(4-((E)-2-(2-氯-4-氟苯基)-1-(1H-吲哚-5-基)丁-1-烯-1-基)苯基)丙烯酸(I)及其盐的方法,以及用于制备(I)的中间体.

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-2024174678-A1
优先权日:2020-06-30
标 题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds

专利号:WO-2024165901-A1
优先权日:2023-02-06
标题 :BENZO[b]SELENOPHENES AS NOVEL SELECTIVE ESTROGEN RECEPTOR MODULATORS
发明人：ARSENJANS PAVELS; PAEGLE EDGARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel benzoselenophenes as anticancer agents by modulating estrogen receptor alpha (ERα) activity, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of various diseases and disorders by administration of such substances.

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.