CAS: 13161-30-3; 2-Pyridinol-1-Oxide

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2-氯吡啶-N-氧化物置于sodium Hydroxide,盐酸体系中,用 水 用作溶剂,以88.36 %的收率获得2-羟基吡啶-N-氧化物
参考文献:2-羟基吡啶-N-氧化物的完全连续流动合成的开发和放大
标题:2-羟基吡啶-N-氧化物的完全连续流动合成的开发和放大
摘要:2-羟基吡啶-N-氧化物 (Hopo) 是一种重要的肽偶联试剂,用于多种药物成分制剂,我们设计,开发并扩大了其完全连续流程合成.该过程涉及使用过氧化氢催化氧化 2-羟基吡啶,然后淬灭和水解以在水溶液中获得 Hopo.设计了具有3D打印静态混合器的混合固定床反应器,以实现原料的完全转化,并开发了涉及酸结晶的连续后处理工艺,以获得高质量的固体hopo产品.连续反应过程和后处理过程导致分离收率>90%,无需额外的分离和纯化步骤,从而避免了连续反应的中断.放大过程成功实现了8公斤/天的生产率,使得该合成方法非常适合工业应用.
Doi:10.1021/acs.Oprd.3C00285

专利信息

专利号:US-7288661-B2
优先权日:2003-12-10
标 题 :Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R represents a hydrogen atom or a protecting group for the amino function.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

专利号:US-7279583-B2
优先权日:2003-12-10
标题:Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of perindopril of formula (I): n nand pharmaceutically acceptable salts thereof.

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.

专利号:US-2014309424-A1
优先权日:2011-06-30
标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine
发明人：BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN
权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA
摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.

专利号:US-4264775-A
优先权日:1976-10-27
标 题:Synthesis of β-aminostyrenes
发明人：WHITE WILLIAM A
权利人:LILLY CO ELI
摘要:A simple process for the preparation of beta -aminostyrenes proceeds from anilines by successively diazotizing, reacting with a vinyl ester, and reacting with a secondary amine without purification of the intermediate products. The compounds are reactive enamines useful in organic synthesis.