专利号:US-6770436-B1 优先权日:1996-11-14 标题:Chemical amplification for the synthesis of patterned arrays 发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
专利号:US-2004110133-A1 优先权日:2002-12-06 标 题 :Functionated photoacid generator for biological microarray synthesis 发明人:XU GUANGYU; GOLDBERG MARTIN 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a chemically amplified polymer matrix is used for the synthesis of polymer arrays.
专利号:US-7053198-B2 优先权日:2002-12-06 标题 :Functionated photoacid generator and functionated polymer system for biological microarray synthesis 发明人:GOLDBERG MARTIN; XU GUANGYU 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a reactive polymer and a photo acid generator is used for the photodirected polymer array synthesis.
专利号:US-5245091-A 优先权日:1990-06-22 标 题 :Process for the preparation of 1,1-bis(chlorophenyl)-2,2,2-trichloroethanol 发明人:CASTELLA SOLA JAUME; PALENCIA ADRUBAU JAIME; COMMANDEUR RAYMOND; GORNY BERNARD 权利人:ATOCHEM ELF SA 摘要:The invention relates to a process for the synthesis of 1,1-bis(chlorophenyl)-2,2,2-trichloroethanol in (dicofol) from chlorol and chlorobenzene, in which process the acid by-products formed during the condensation reaction of the chloral and the chlorobenzene are used as reaction medium in the final step for synthesis of dicofol.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
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