CAS: 105107-84-4; Cis-4-Phenylthio-L-Proline Hydrochloride

英文名称Cis-4-Phenylthio-L-Proline Hydrochloride
中文名称顺式-4-苯硫基-L-脯氨酸盐酸盐
IUPAC名称(2S,4S)-4-(phenylthio)pyrrolidine-2-carboxylic acid hydrochloride
其它别名(2S,4S)-4-苯硫基-L-脯氨酸盐酸盐; Cis-4-Phenylthio-L-Proline Hydrochloride(Zofenopril Calcium)
CAS编号105107-84-4
MFCD编号:MFCD11109939
分子式:C11H14ClNO2S
分子量:259.75
产品CID: 91690
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: XXNAGGDFBCTLQA-DHTOPLTISA-N
InChI=1S/C11H13NO2S.ClH/c13-11(14)10-6-9(7-12-10)15-8-4-2-1-3-5-8;/h1-5,9-10,12H,6-7H2,(H,13,14);1H/t9-,10-;/m0./s1…
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数3.0

相似化合物

1353995-35-3 1289584-92-4 83623-88-5

物理性质

熔点151-153 °C
PSA:49.33
LogP:2.0156
溶解性DMSO (Slightly), Methanol (Slightly), Water (Slightly)
外观形态白色固体
储存条件密封, 常温干燥保存

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

CAS号108-98-5 硫酚 | CAS号57653-38-0 N-[(phenylmetho... | CAS号81872-10-8 佐芬普利

合成工艺路线路线简述

(2S,4S)-4-(Phenylsulfanyl)-Pyrrolidine-1,2-Dicarboxylic Acid 1-Tert-Butyl Ester置于盐酸体系中,用 1,4-二氧六环用作溶剂,化学反应 2.0H,反应生成顺式-4-苯硫基-L-脯氨酸盐酸盐
参考文献:Ep2058301
标题:Ep2058301

海关参考信息

2905130000-正丁醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2011281928-A1
优先权日:2009-01-23
标题:Process for the preparation of zofenopril and its pharmaceutically acceptable salts thereof
发明人：KHAN MUBEEN AHMED; YADAV ROOP SINGH; TRIVEDI NIKHIL RASIKLAL; LAD SACHIN MAHEDO
权利人:KHAN MUBEEN AHMED; YADAV ROOP SINGH; TRIVEDI NIKHIL RASIKLAL; LAD SACHIN MAHEDO; GLENMARK GENERICS LTD
摘要:The present invention relates to a process for the preparation of zofenopril and its pharmaceutically acceptable salts and a pharmaceutical composition thereof. The present invention also provides structurally novel compounds, which are useful intermediates in the synthesis of zofenopril.